The homeobox genes encode transcription factors that regulate developmental processes such as body patterning and organogenesis. The mammalian HOX gene complex consists of 39 genes that are located on 4 linkage groups (clusters), dispersed over 4 chromosomes (HOXA, HOXB, HOXC and HOXD). HOXB7 is expressed in most malignant T-cell lines and CD4-positive peripheral blood cells, and is constitutively expressed in both melanoma primary lesions and cell lines. HOXB7 binds to and transactivates bFGF in melanoma cell lines but SkBr3 breast adenocarcinoma is negative for the expression of both HOXB7 and bFGF genes. HOXB7 may be a key activator of tumor-associated neoangiogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: homeo box 2C; homeo box B7; homeo box c1 protein; homeobox gene B7; Homeobox protein HHO.C1; Homeobox protein Hox-2.3; Homeobox protein Hox-2C; Homeobox protein Hox-B7; Homeobox protein MH-22B; Homeobox protein MuB1; Homeobox protein R1B; Hox-23
Gene Aliases: AI325018; HHO.C1; Hox-2.3; HOX2; HOX2C; Hox2r1b; Hoxb-7; HOXB7; R1b
Molecular Function: homeodomain transcription factor