This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the regulation of cartilage differentiation. It could also be involved in chondrodysplasias or other cartilage disorders.
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Protein Aliases: homeo box 3A; homeo box C8; Homeobox gene C8; Homeobox protein Hox-3.1; Homeobox protein Hox-3A; Homeobox protein Hox-C8; Homeobox protein M31; homeobox protein R4; Hox-3.1, mouse, homolog of
Gene Aliases: D130011F21Rik; Hox-3.1; HOX3; HOX3A; Hox3r4; Hoxc-8; HOXC8