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Invitrogen
HOXD11 Polyclonal Antibody
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FIGURE: 1 / 12
HOXD11 Antibody (PA5-144013) in ICC/IF
Immunocytochemistry analysis of HOXD11 in A431 cells. Enzyme antigen retrieval was performed using IHC enzyme antigen retrieval reagent for 15 mins. The cells were blocked with 10% goat serum. Samples were then incubated in HOXD11 Polyclonal antibody (Product # PA5-144013) using a dilution of 5 μg/mL. DyLight®488 Conjugated Goat Anti-Rabbit IgG was used as secondary antibody at 1:100 dilution and incubated for 30 minutes at 37°C. The section was counterstained with DAPI. Visualize using a fluorescence microscope and filter sets appropriate... View More
Product Details
PA5-144013
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence of human HOXD11 (VREVAFRDYGLERAKWPYR).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
0.01mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Positive Control - WB: human K562 whole cell, human Hek293 whole cell, human U87 whole cell, human A431 whole cell, human A549 whole cell, mouse kidney tissue. IHC: human melanoma tissue, human ovarian cancer tissue, human skin cancer tissue, human testicular cancer tissue. ICC/IF: A431 cell. Flow: 293T cell, NRK cell, RAW2647 cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
HOX11, also called homeobox11 or Tcl-3 is located at the 10q24 T-Cell translocation breakpoint region. It encodes a homeobox-domain containing protein, HOX11, containing a glycine and proline-rich amino terminus. HOX11 is required for maintenance of the developing spleen and cell survival. The HOX11protein binds to a specific DNA sequence and localizes to the cell nucleus. It transactivates transcription of a reporter gene linked to a cis-regulatory element, acting as a positive transcription activator. The HOX11 gene is highly expressed in T-ALLs as a result of a t (7:10) (q35;q24) or t(10:14)(q24;qll) translocation. The homeobox gene is deregulated upon translocation into the T-cell receptor locus and activates a specific subset of tumor-associated target genes. HOX 11 gene translocation has been attributed to T-cell leukemia and lymphoid neoplasias.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: homeo box 4F; homeo box D11; Homeobox protein Hox-4.6; Homeobox protein Hox-4F; Homeobox protein Hox-5.5; Homeobox protein Hox-D11; Hox-4.6, mouse, homolog of; HOX11; uncharacterized LOC102553842
Gene Aliases: E230017H14Rik; Hox-4.6; Hox-5.4; Hox-5.5; HOX4; HOX4F; Hoxd-11; HOXD11
UniProt ID: (Human) P31277, (Mouse) P23813
Entrez Gene ID: (Human) 3237, (Mouse) 15431, (Rat) 102553842
branching involved in ureteric bud morphogenesis
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
dorsal/ventral pattern formation
embryonic skeletal joint morphogenesis
skeletal system development
metanephros development
organ induction
transcription, DNA-templated
multicellular organism development
single fertilization
pattern specification process
anterior/posterior pattern specification
proximal/distal pattern formation
regulation of gene expression
positive regulation of cell development
embryonic limb morphogenesis
regulation of chondrocyte differentiation
positive regulation of chondrocyte differentiation
embryonic forelimb morphogenesis
embryonic digit morphogenesis
developmental growth
cartilage development involved in endochondral bone morphogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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