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Product Details
BS-12197R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human HOXD13, amino acids 251-343.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
HOXD13 (homeobox protein D13) belongs to a class of transcription factors called homeobox proteins. In vertebrates, homeobox are found in clusters called A, B, C, and D on four separate chromosomes. Expression of homeobox proteins is spatially and temporally regulated during embryonic development. The gene encoding HOXD13 is part of the D cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. Mutations in the HOXD13 gene cause synpolydactyly.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: homeo box 4I; homeo box D13; Homeobox protein Hox-4.8; Homeobox protein Hox-4I; Homeobox protein Hox-D13
Gene Aliases: BDE; BDSD; Hox-4.8; HOX4I; HOXD13; SPD; SPD1; spdh
UniProt ID: (Human) P35453, (Mouse) P70217
Entrez Gene ID: (Human) 3239, (Rat) 288154, (Mouse) 15433
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
chromatin binding
molecular_function
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
skeletal system development
transcription from RNA polymerase II promoter
pattern specification process
anterior/posterior pattern specification
gland morphogenesis
embryonic limb morphogenesis
male genitalia development
limb morphogenesis
regulation of cell proliferation
embryonic digit morphogenesis
positive regulation of transcription from RNA polymerase II promoter
embryonic hindgut morphogenesis
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
morphogenesis of an epithelial fold
branch elongation of an epithelium
regulation of branching involved in prostate gland morphogenesis
regulation of transcription, DNA-templated
multicellular organism development
transcription, DNA-templated
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