This target displays homology in the following species: Cow: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 77%
HOXD13 (homeobox protein D13) belongs to a class of transcription factors called homeobox proteins. In vertebrates, homeobox are found in clusters called A, B, C, and D on four separate chromosomes. Expression of homeobox proteins is spatially and temporally regulated during embryonic development. The gene encoding HOXD13 is part of the D cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. Mutations in the HOXD13 gene cause synpolydactyly.
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Protein Aliases: homeo box 4I; homeo box D13; homeobox D13; Homeobox protein Hox-4.8; Homeobox protein Hox-4I; Homeobox protein Hox-D13
Gene Aliases: BDE; BDSD; Hox-4.8; HOX4I; HOXD13; SPD; SPD1; spdh