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Abnova
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FIGURE: 1 / 1
Sequence of this protein is as follows: MSSYFVNPLY SKYKAAAAAA AAAGEAINPT YYDCHFAPGV GGRHAAAAAA LQLYGNSAAG FPHAPPQAHA HPHPSPPPSG TGCGGREGRG QEYFHPGGGS PAAAYQAAPP PPPHPPPPPP PPPCGGIACH GEPAKFYGYD NLQRQPIFTT QQEAELVQYP DCKSSSGNIG EDPDHLNQSS SPSQMFPWMR PQAPGRRRGR QTYSRFQTLE LEKEFLFNPY LTRKRRIEVS HALALTERQV KIWFQNRRMK WKKENNKDKF PVSRQEVKDG ETKKEAQELE EDRAEGLTN
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function.
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