|Flow Cytometry (Flow)||1:100|
|Immunohistochemistry (Paraffin) (IHC (P))||1:200|
|Western Blot (WB)||1:1000|
|Tested Species reactivity||Bovine, Human, Mouse, Non-human primate, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to the carboxy terminus of human HP1alpha|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/ml BSA, 50% glycerol|
It is not recommended to aliquot this antibody.
This antibody is not cross-reactive with HP1 beta or HP1 gamma proteins.
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Antigen p25; chromobox homolog 5; chromobox homolog 5 (HP1 alpha homolog, Drosophila); Chromobox protein homolog 5; chromobox-like protein 5; epididymis luminal protein 25; heterochromatin protein 1 alpha; Heterochromatin protein 1 homolog alpha; heterochromatin protein 1-alpha; HP1 alpha; HP1 alpha homolog; HP1-ALPHA; HP1Hs alpha; mHP1(alpha)
Gene Aliases: 2610029O15Rik; BOS_4984; C75991; CBX5; HEL25; HP1; HP1A; Hp1alpha
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