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Invitrogen
HPD Polyclonal Antibody
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FIGURE: 1 / 4
HPD Antibody (PA5-119747) in IHC (P)
Immunohistochemistry (Paraffin) analysis of paraffin-embedded mouse liver tissue using HPD Polyclonal Antibody (Product # PA5-119747). The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the HPD antibody at a dilution of 1:80... View More
Product Details
PA5-119747
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein within human HPD aa 1-200.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.4, with 50% glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control: Rat liver tissue lysate, human kidney tissue lysate, rat kidney tissue, human liver tissue, mouse liver tissue.
Subcellular Location: Cytosol, endoplasmic reticulum membrane, extracellular exosome, golgi membrane.
Target Information
The inhibitor of apoptosis (IAP) family of proteins regulates programmed cell death triggered by various stimuli. All IAPs have at least one baculovirus IAP repeat (BIR) motif that is essential for their anti-apoptotic activity (1-3). Recently, a serine protease has been isolated, which is released from the mitochondria upon induction of apoptosis by apoptotic stimuli. This protein called Omi/HtrA2 is a mitochondrial protein that binds to IAP (4). Like Smac/DIABLO, the mature Omi protein contains a conserved IAP-binding motif (AVPS) at its N terminus. The deregulated expression of Omi in the cytoplasm of mammalian cells induces apoptosis indicating that Omi could participate in the mitochondrial apoptotic pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 4-H HPPDASE; 4-hydroxyphenylpyruvate dioxygenase; 4-hydroxyphenylpyruvic acid dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; 4H GLOD3; 4HPPD; F Alloantigen; F liver antigen; F protein; glyoxalase domain containing 3; HPPDase; p-hydroxyphenylpyruvate dioxygenase; unnamed protein product
Gene Aliases: 4-HPPD; 4HPPD; Fla; Flp; GLOD3; HPD; HPPD; HPPDASE; Laf; PPD
UniProt ID: (Human) P32754, (Mouse) P49429, (Rat) P32755
Entrez Gene ID: (Human) 3242, (Mouse) 15445, (Rat) 29531
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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