Peptide sequence: CLPSKNYAEV GRVGYVSGWG QSDNFKLTDH LKYVMLPVAD QYDCITHYEG
Sequence homology: Human: 100%
This gene encodes a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may also be a clinically important predictor of recurrence of breast cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Haptoglobin-related locus; Haptoglobin-related protein
Gene Aliases: A-259H10.2; HP; HPR
UniProt ID: (Human) P00739
Entrez Gene ID: (Human) 3250
Molecular Function: annexin calcium-binding protein calmodulin enzyme modulator hydrolase intracellular calcium-sensing protein peptide hormone protease protease inhibitor receptor serine protease signaling molecule