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Invitrogen
HRD1 Polyclonal Antibody
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Product Details
PA1-46121
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Hamster,
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide made to an internal portion of human HRD1 (within residues 300-400).
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Suggested positive control: 293T, INS-1, and MIN6 cell lysates, antigen standard for SYVN1 (transient overexpression lysate).
Target Information
HRD1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of HRD1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. HRD1 is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney and skeletal muscle. It has been reported that Synoviolin/Hrd1 (expressed in rheumatoid synovium) is a novel causative factor for arthropathy by triggering synovial cell outgrowth through its anti-apoptotic effects. HRD1 contains one ring-type zinc finger.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E3 ubiquitin-protein ligase synoviolin; HMG-coA reductase degradation 1 homolog; MGC40372; required for ER protein degradation; RING-type E3 ubiquitin transferase synoviolin; Synovial apoptosis inhibitor 1; synovial apoptosis inhibitor 1, synoviolin; synoviolin 1; unnamed protein product
Gene Aliases: 1200010C09Rik; AW211966; C85322; D530017H19Rik; DER3; HRD1; I79_023844; KIAA1810; SYVN1
UniProt ID: (Human) Q86TM6, (Mouse) Q9DBY1
Entrez Gene ID: (Human) 84447, (Mouse) 74126, (Chinese hamster) 100765313
protein binding
zinc ion binding
transferase activity
metal ion binding
unfolded protein binding
chaperone binding
ATPase binding
ubiquitin protein ligase activity
DNA-binding transcription factor binding
ubiquitin-specific protease binding
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ligase activity
ribosomal S6-glutamic acid ligase activity
activating transcription factor binding
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
in utero embryonic development
response to unfolded protein
multicellular organism development
protein ubiquitination
protein N-linked glycosylation via asparagine
protein catabolic process
ER-associated ubiquitin-dependent protein catabolic process
retrograde protein transport, ER to cytosol
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
immature B cell differentiation
negative regulation of T-helper 1 type immune response
ubiquitin-dependent protein catabolic process
ERAD pathway
proteasome-mediated ubiquitin-dependent protein catabolic process
protein stabilization
protein K48-linked ubiquitination
endoplasmic reticulum mannose trimming
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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