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Invitrogen
HRD1 Polyclonal Antibody
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Product Details
PA5-82191
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SYVN1. Recombinant protein control fragment (Product #RP-89210).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PAPGFPFPPP WMGMPLPPPF AFPPMPVPPA GFAGLTPEEL RALEGHERQH LEARLQSLRN IHTLLDAAML QINQYLTVLA SLGPPRPATS VNSTEETATT VVAAASSTSI PSSEATTPTP GASPPAPEME RPPAPESVGT
Highest antigen sequence indentity to the following orthologs: Mouse - 92%, Rat - 90%.
Target Information
HRD1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of HRD1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. HRD1 is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney and skeletal muscle. It has been reported that Synoviolin/Hrd1 (expressed in rheumatoid synovium) is a novel causative factor for arthropathy by triggering synovial cell outgrowth through its anti-apoptotic effects. HRD1 contains one ring-type zinc finger.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E3 ubiquitin-protein ligase synoviolin; HMG-coA reductase degradation 1 homolog; MGC40372; required for ER protein degradation; RING-type E3 ubiquitin transferase synoviolin; Synovial apoptosis inhibitor 1; synovial apoptosis inhibitor 1, synoviolin; unnamed protein product
Gene Aliases: DER3; HRD1; KIAA1810; SYVN1
UniProt ID: (Human) Q86TM6
Entrez Gene ID: (Human) 84447
immature B cell differentiation
negative regulation of T-helper 1 type immune response
ubiquitin-dependent protein catabolic process
protein ubiquitination
retrograde protein transport, ER to cytosol
ERAD pathway
proteasome-mediated ubiquitin-dependent protein catabolic process
protein stabilization
protein K48-linked ubiquitination
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
endoplasmic reticulum mannose trimming
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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