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Invitrogen
HRH4 Polyclonal Antibody
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FIGURE: 1 / 2
HRH4 Antibody (PA5-85626) in WB
HRH4 Polyclonal Antibody detects Histamine H4 Receptor protein by western blot analysis. HL-60 whole cell extracts and membrane extracts (unboiled) (30 µg) were separated by 10% SDS-PAGE, and the membrane was blotted with HRH4 Polyclonal Antibody (Product # PA5-85626) diluted at 1:1,000.
Product Details
PA5-85626
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
The immunogen used to generate this antibody corresponds to human Histamine H4 Receptor.
Conjugate
Form
Liquid
Concentration
2.85 mg/mL
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Keep as concentrated solution.
Positive Control: HL-60 MF (unboiled).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The Histamine H4 receptor has been reported in human blood peripheral leukocytes, bone marrow, colon, liver, lung, smalll intestine, spleen, testis, thymus, tonsil, and trachea. Contrary to the mouse H4 receptor, the human gene was not detected in brain. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more thana thousandmembers currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Twoblockbuster drugs which have been developed as GPCR-targetedpharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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