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Beta Actin Recombinant Rabbit Monoclonal Antibody (4H1), HRP

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Beta Actin Recombinant Rabbit Monoclonal Antibody (4H1), HRP

Product Details

HRP-81115

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000-1:16,000
-
Product Specifications

Species Reactivity

Human, Mouse, Pig, Rat

Host/Isotype

Rabbit / IgG

Expression System

CHO cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

4H1

Immunogen

Beta Actin fusion protein Ag14521
3D Epitope / Immunogen

Conjugate

HRP HRP HRP

Form

Liquid

Concentration

1000 µg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 0.5% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, store in dark

Shipping conditions

Wet ice

Product Specific Information

Sequence of this protein is as follows: MDDDIAALVV DNGSGMCKAG FAGDDAPRAV FPSIVGRPRH QGVMVGMGQK

Target Information

Beta actin is one of six actin isoforms which have been identified. Beta actin is a non-muscle cytoskeletal protein in all human cell types and is involved in cell motility, structure, and integrity. There are six different actin isoforms in human. The beta isoform of actin, along with gamma actin, coexist in most cell types as components of the cyto-skeleton. Beta actins are cytoplasmic proteins ubuquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of two stranded helix. Actins are highly conserved proteins that are involved in cell motility, structure and integrity. Because beta actin is ubiquitously expressed in all eukaryotic cells, it is frequently used as a loading control for assays involving protein detection, such as Western blotting. Antibodies to beta-actin provide a specific and useful tool in studying the intracellular distribution of beta-actin and the static and dynamic aspects of the cytoskeleton.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: A-X actin; A-X actin-like protein; Actin is a protein with a high degree of evolutionary conservation that undergoes polymerization to generate filaments, which subsequently assemble into interconnected networks within the cytoplasm of cells.; actin, beta, cytoplasmic; beta actin; beta cytoskeletal actin; beta-actin; cytoplasmic beta-actin; cytoplasmic protein; cytoskeletal beta actin; I(2)-actin; melanoma X-actin; PS1TP5-binding protein 1; unnamed protein product

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Gene Aliases: Actx; beta-actin; BKRNS; BNS; BRWS1; CSMH; DDS1; E430023M04Rik; PS1TP5BP1; THC8

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UniProt ID: (Pig) Q6QAQ1, (Human) P60709, (Mouse) P60710, (Rat) P60711

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Entrez Gene ID: (Pig) 414396, (Human) 60, (Mouse) 11461, (Rat) 81822

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Function(s)
protein binding ATP binding structural constituent of cytoskeleton ATPase activity kinesin binding protein kinase binding nitric-oxide synthase regulator activity Tat protein binding nucleosomal DNA binding identical protein binding tau protein binding nitric-oxide synthase binding structural constituent of postsynaptic actin cytoskeleton transporter regulator activity actin and actin related protein actin or actin-binding cytoskeletal protein cytoskeletal protein
Process(es)
postsynaptic actin cytoskeleton organization morphogenesis of a polarized epithelium chromatin remodeling regulation of transcription from RNA polymerase II promoter cytoskeleton organization microtubule nucleation establishment or maintenance of cell polarity axonogenesis positive regulation of cell proliferation substantia nigra development regulation of mitotic metaphase/anaphase transition adherens junction assembly maintenance of blood-brain barrier regulation of apoptotic process apical protein localization positive regulation of T cell differentiation negative regulation of cell differentiation positive regulation of cell differentiation positive regulation of myoblast differentiation positive regulation of transcription, DNA-templated cell motility regulation of norepinephrine uptake positive regulation of norepinephrine uptake regulation of cell cycle regulation of G0 to G1 transition platelet aggregation protein localization to adherens junction cellular response to cytochalasin B regulation of transepithelial transport regulation of synaptic vesicle endocytosis positive regulation of stem cell population maintenance positive regulation of double-strand break repair via homologous recombination regulation of G1/S transition of mitotic cell cycle regulation of double-strand break repair positive regulation of double-strand break repair regulation of nucleotide-excision repair cellular response to electrical stimulus regulation of protein localization to plasma membrane circadian rhythm response to mechanical stimulus dynein-driven meiotic oscillatory nuclear movement response to immobilization stress retina development in camera-type eye
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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