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Invitrogen

HRX Polyclonal Antibody

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HRX Polyclonal Antibody

Product Details

720133

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20
-

Immunocytochemistry (ICC/IF)

1 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Protein corresponding to Human KMT2A (aa 700-1000)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2, with 0.1% BSA, 30% glycerol

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2608137

Product Specific Information

These Polyclonal antibodies are of rabbit origin developed by immunizing animals with proteins or peptides. The polyclonal antibody is purified by affinity purification from the rabbit sera generated after immunizing the rabbits with a specific type of protein or peptide. The purified antibody is tested for its functionality in various relevant research applications. The antibody is developed for Research Use Only and is non-hazardous or non-infectious in nature.

This antibody is predicted to react with Monkey, Equine, Pig, Bovine, Rabbit, Rat and Mouse.

Target Information

KMT2A is a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, KMT2A specifically mediates H3K4me, a tag for epigenetic transcriptional activation. KMT2A has weak methyltransferase activity by itself, and requires other components of the MLL1/MLL complex to obtain full methyltransferase activity. It has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', and has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9 and promotes PPP1R15A-induced apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ALL-1; CDK6/MLL fusion protein; CXXC-type zinc finger protein 7; Cysteine methyltransferase KMT2A; Histone-lysine N-methyltransferase 2A; lysine (K)-specific methyltransferase 2A; Lysine N-methyltransferase 2A; mixed lineage leukemia 1; MLL-AF4 der(11) fusion protein; MLL/ENL fusion protein; MLL/GAS7 fusion protein; MLL/GMPS fusion protein; MLL/hCDCrel fusion protein; Myeloid/lymphoid or mixed-lineage leukemia; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); Myeloid/lymphoid or mixed-lineage leukemia protein 1; rearranged MLL protein; Trithorax-like protein; Zinc finger protein HRX

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Gene Aliases: ALL-1; ALL1; CXXC7; HRX; HTRX; HTRX1; KMT2A; MLL; MLL-AF9; MLL/GAS7; MLL1; MLL1A; TET1-MLL; TRX1; WDSTS

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UniProt ID: (Human) Q03164

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Entrez Gene ID: (Human) 4297

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Function(s)
core promoter sequence-specific DNA binding AT DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding zinc ion binding histone-lysine N-methyltransferase activity histone methyltransferase activity (H3-K4 specific) identical protein binding protein homodimerization activity transcription regulatory region DNA binding unmethylated CpG binding lysine-acetylated histone binding histone modifying enzyme
Process(es)
DNA methylation transcription from RNA polymerase II promoter protein complex assembly apoptotic process negative regulation of cell proliferation visual learning post-embryonic development anterior/posterior pattern specification peptidyl-lysine monomethylation positive regulation of transporter activity circadian regulation of gene expression embryonic hemopoiesis exploration behavior response to potassium ion histone H4-K16 acetylation histone H3-K4 dimethylation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of short-term neuronal synaptic plasticity spleen development homeostasis of number of cells within a tissue histone H3-K4 methylation positive regulation of histone H3-K4 methylation membrane depolarization definitive hemopoiesis regulation of histone H3-K14 acetylation histone H3-K4 trimethylation regulation of histone H3-K27 acetylation regulation of histone H3-K9 acetylation positive regulation of cellular response to drug
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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