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|Tested species reactivity||Human|
|Published species reactivity||Not Applicable|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 3879-3908 amino acids from the C-terminal region of human HRX|
|Purification||Size-exclusion - Dialysis, Ammonium sulfate precipitation|
|Contains||0.09% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1:10-1:50|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 1 publications below|
The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. Tse et al. (1995) characterized 2 t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21, AF1Q, in 2 infants with acute myelomonocytic leukemia. In one of these patients, the derivative chromosome 11 represented an in-frame fusion of the N-terminal portion of the MLL gene to the complete AF1Q open reading frame, whereas the derivative chromosome 1 did not give rise to an open reading frame. This observation suggested that the N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Not Applicable||Not Cited||
GRHL3/GET1 and trithorax group members collaborate to activate the epidermal progenitor differentiation program.
PA5-11264 was used in immunohistochemistry to elucidate how Trithorax regulates epidermal differentiation
|Hopkin AS,Gordon W,Klein RH,Espitia F,Daily K,Zeller M,Baldi P,Andersen B||PLoS genetics (8:null)||2012|
ALL-1; CDK6/MLL fusion protein; CXXC-type zinc finger protein 7; Histone-lysine N-methyltransferase 2A; lysine (K)-specific methyltransferase 2A; Lysine N-methyltransferase 2A; mixed lineage leukemia 1; MLL-AF4 der(11) fusion protein; MLL/ENL fusion protein; MLL/GAS7 fusion protein; MLL/GMPS fusion protein; MLL/hCDCrel fusion protein; Myeloid/lymphoid or mixed-lineage leukemia; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); Myeloid/lymphoid or mixed-lineage leukemia protein 1; rearranged MLL protein; Trithorax-like protein; Zinc finger protein HRX
ALL-1; ALL1; CXXC7; HRX; HTRX; HTRX1; KMT2A; MLL; MLL-AF9; MLL/GAS7; MLL1; MLL1A; TET1-MLL; TRX1; WDSTS