Immunogen sequence: GATELYRTGKK SHLRKTTEKK LPTKQTIAKL QQSDIWKMEN EFYEFALEQF QFIRAHAVRE KDGDLYILAQ
Highest antigen sequence identity to the following orthologs - mouse 99%, rat 97%.
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes a member of the heparan sulfate biosynthetic enzyme family that transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate. The disruption of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme may interfere with the signaling required for kidney formation. Two alternatively spliced transcript variants that encode different proteins have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.