Immunogen sequence: MGLLRIMMPP KLQLLAVVAF AVAMLFLENQ IQKLEESRSK LERAIARHEV REIEQRHTMD GPRQDATLDE EEDMVIIYNR VPKTASTSFT NIAYDLCAKN KYHVLHINTT KNNPVMSLQD QVRFVKNITS WKEMKPGFYH GHVSYLDFAK FGVKKKPIYI NVIRDPIERL VSYYYFLRFG DDYRPGLRRR KQGDKKTFDE CVAEGGSDCA PEKLWLQIPF FCGHSSECW; Positive Samples: U-87MG, Mouse lung, Rat thymus; Cellular Location: Golgi apparatus membrane, Single-pass type II membrane protein
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes a member of the heparan sulfate biosynthetic enzyme family that transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate. The disruption of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme may interfere with the signaling required for kidney formation. Two alternatively spliced transcript variants that encode different proteins have been found for this gene.
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Protein Aliases: 2-O-sulfotransferase; 2-OST; 2OST; Heparan sulfate 2-O-sulfotransferase 1
Gene Aliases: AW214369; dJ604K5.2; HS2ST; HS2ST1; KIAA0448; mKIAA0448
Molecular Function: transferase