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Invitrogen
HS6ST1 Polyclonal Antibody
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Product Details
PA5-111203
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human HS6ST1. Recombinant protein control fragment (Product #RP-96091).
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: QRYQYKRQLE RREQRLRSRE ERLLHRAKEA LPREDADEPG RVPTEDYMSH IIEKW
Highest antigen sequence indentity to the following orthologs: Rat - 93%, Mouse - 93%.
Target Information
The HS6ST1 gene encodes the enzyme heparan sulfate 6-O-sulfotransferase 1, which is essential for the biosynthesis of heparan sulfate (HS) glycosaminoglycans by adding sulfate groups to the 6th position of glucosamine residues within HS chains. HS6ST1 is vital for numerous biological processes, including modulating the activity of growth factors, cytokines, and chemokines, which are influenced by HS structures on the cell surface and extracellular matrix. This sulfation step is critical for the proper functioning of developmental pathways and neuronal signaling, impacting brain development and function. Mutations in HS6ST1 have been associated with intellectual disabilities and developmental disorders such as hypogonadotropic hypogonadism and Kallmann syndrome, characterized by impaired sense of smell and delayed puberty. Moreover, altered HS6ST1 expression is implicated in cancer progression by affecting tumor growth, angiogenesis, and metastasis through altered HS interactions with signaling molecules. Its role in modulating receptor-ligand interactions makes HS6ST1 a promising target for therapeutic interventions aimed at repairing defective signaling pathways associated with genetic disorders and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Heparan-sulfate 6-O-sulfotransferase 1; heparan-sulfate 6-sulfotransferase; HS6ST-1
Gene Aliases: HH15; HS6ST; HS6ST1
UniProt ID: (Human) O60243
Entrez Gene ID: (Human) 9394
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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