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Invitrogen
HSC70 Polyclonal Antibody
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Product Details
PA5-29241
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human HSC70. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.79 mg/mL
Amount
79 µg
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji, Raw264.7, mouse brain.
Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (97%), Xenopus laevis (98%), Pig (100%), Chicken (100%), Rhesus Monkey (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The HSP70 family is a set of highly conserved proteins that are induced by a variety of biological stresses, including heat stress, in every organism in which the proteins have been examined. The human HSP70 family members include: HSP70, a protein which is strongly inducible in all organisms but which is also constitutively expressed in primate cells; HSP72, a 72 kDa protein that is induced exclusively under stress conditions; HSC70, or cognate protein, is a 72 kDa, constitutively expressed, protein which is involved in the uncoating of clathrin coated vesicles; GRP78, or BiP, is a glucose regulated 78 kDa protein localized in the endoplasmic reticulum; and p75, or HSP75, a 75 kDa protein that is found within the mitochondria. HSC70 (also known as HSC71, HSC73, HSP73, p72, prp73) is expressed constitutively and is slightly heat-inducible. HSC70 binds to the exposed loop of clathrin light chains to promote uncoating and can also bind the cytoskeleton which may facilitate cytoskeletal rearrangements. HSC70 has been shown to stimulate lysosomal degradation of intracellular proteins and to retard both aggregation and folding of mitochondrial precursor proteins in vitro.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AAG2; constitutive heat shock protein 70; epididymis luminal protein 33; epididymis secretory sperm binding protein Li 72p; FAM10A1; Heat shock 70 kDa protein 8; heat shock 70kd protein 10; heat shock 70kD protein 8; heat shock 70kDa protein 8; Heat shock cognate 71 kDa protein; heat shock cognate hsc73; heat shock cognate protein 54; heat shock protein cognate 70; Heat shock protein family A member 8; HIP; LAP; LAP-1; Lipopolysaccharide-associated protein 1; LPS-associated protein 1; MGC131511; MGC29929; N-myristoyltransferase inhibitor protein 71; Protein FAM10A1; SNC6; unnamed protein product
Gene Aliases: 2410008N15Rik; HEL-33; HEL-S-72p; HSC54; HSC70; HSC71; Hsc73; HSP71; HSP73; HSPA10; HSPA8; LAP-1; LAP1; NIP71
UniProt ID: (Human) P11142, (Mouse) P63017
Entrez Gene ID: (Human) 3312, (Pig) 100511890, (Mouse) 15481
nucleotide binding
G-protein coupled receptor binding
RNA binding
protein binding
ATP binding
hydrolase activity
ATPase activity
enzyme binding
MHC class II protein complex binding
protein binding, bridging
heat shock protein binding
ubiquitin protein ligase binding
protein binding involved in protein folding
cadherin binding
receptor agonist activity
unfolded protein binding
chaperone binding
C3HC4-type RING finger domain binding
ATP-dependent protein disaggregase activity
ATP-dependent protein folding chaperone
receptor binding
ATPase activity, coupled
ADP binding
poly(A) RNA binding
mRNA splicing, via spliceosome
mRNA processing
protein folding
autophagy
response to unfolded protein
signal transduction
RNA splicing
cellular response to starvation
negative regulation of signal transduction
protein catabolic process
positive regulation of cell migration
regulation of protein stability
cellular response to stress
regulation of cytoplasmic pattern recognition receptor signaling pathway
protein refolding
regulation of protein complex assembly
negative regulation of transcription, DNA-templated
ATP metabolic process
negative regulation of cellular component organization
membrane organization
regulation of protein complex stability
chaperone-mediated autophagy
protein targeting to lysosome involved in chaperone-mediated autophagy
cellular response to steroid hormone stimulus
clathrin coat disassembly
negative regulation of NLRP3 inflammasome complex assembly
regulation of fibril organization
negative regulation of fibril organization
regulation of protein import
chaperone-mediated autophagy translocation complex disassembly
transcription, DNA-templated
regulation of transcription, DNA-templated
positive regulation of mRNA splicing, via spliceosome
chaperone mediated protein folding requiring cofactor
regulation of cell cycle
chaperone-mediated protein folding
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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