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Invitrogen
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
0.1-0.5 µg/mL | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
0.5-1 µg/mL | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
A synthetic peptide corresponding to a sequence at the N-terminus of human HSD11B1. |
Conjugate |
Unconjugated |
Form |
Lyophilized |
Concentration |
500 µg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS with 5mg BSA |
Contains |
0.05mg sodium azide, 0.05mg thimerosal |
Storage conditions |
-20°C |
RRID |
AB_2746514 |
The synthetic peptide sequence is 16-33aa, MAYYYYSANEEFRPEMLQ
Add 0.2 mL of distilled water, will yield a concentration of 500 µg/mL.
HSD11B1 is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, HSD11B1 can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Two transcript variants encoding the same protein have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 11-beta-HSD1; 11-beta-hydroxysteroid dehydrogenase 1; 11-DH; 11beta-HSD-1; 11beta-HSD1A; 11beta-hydroxysteroid dehydrogenase type 1; Corticosteroid 11-beta-dehydrogenase isozyme 1; Corticosteroid 11-beta-dehydrogenase, isozyme 1 (11-DH) (11-beta-hydroxysteroid dehydrogenase 1) (11-beta-HSD1) (11beta-HSD1A); cortocosteroid 11-beta dehydrogenase; hydroxysteroid (11-beta) dehydrogenase 1; hydroxysteroid dehydrogenase, 11 beta type 1; MGC13539; OTTHUMP00000034650; Short chain dehydrogenase/reductase family 26C member 1; short chain dehydrogenase/reductase family 26C, member 1
Gene Aliases: 11-beta-HSD1; 11-DH; CORTRD2; HDL; HSD11; HSD11B; HSD11B1; HSD11L; LRRGT00065; SDR26C1
UniProt ID: (Human) P28845, (Rat) P16232, (Mouse) P50172
Entrez Gene ID: (Human) 3290, (Rat) 25116, (Mouse) 15483
Molecular Function:
dehydrogenase
reverse transcriptase
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