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Immunogen sequence: MWLYLAAFV GLYYLLHWYR ERQVVSHLQD KYVFITGCDS GFGNLLARQL DARGLRVLAA CLTEKGAEQL RGQTSDRLET VTLDVTKMES IAAATQWVKE HVGDRGLWGL VNNAGILTPI TLCEWLNTED SMNMLKVNLI GVIQVTLSML PLVRRARGRI VNVSSILGRV AFFVGGYCVS KYGVEAFSDI LRREIQHFGV KISIVEPGYF RTGMTNMTQS LERMKQSWKE APKHIKETYG QQYFDALYNI MKEGLLNCST NLNLVTDCME HALTSVHPRT RYSAGWDAKF FFIPLSYLPT SLADYILTRS WPKPAQAV (1-317 aa encoded by BC020710)
The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of the retinol dehydrogenase family. Transcript variants utilizing alternative polyadenylation signals exist.
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Protein Aliases: 17-beta-HSD 6; 17-beta-HSD6; 17-beta-HSD9; 17-beta-hydroxysteroid dehydrogenase type 6; 3(alpha->beta)-hydroxysteroid epimerase; 3(alpha->beta)-hydroxysteroid epimerasel; 3-alpha->beta-HSE; 3-alpha->beta-hydroxysteroid epimerase; 3-hydroxysteroid epimerase; hydroxysteroid (17-beta) dehydrogenase 6 homolog; hydroxysteroid (17-beta) dehydrogenase 9; hydroxysteroid 17-beta dehydrogenase 9; NAD+ -dependent 3 alpha-hydroxysteroid dehydrogenase 3-hydroxysteroid epimerase; oxidative 17 beta hydroxysteroid dehydrogenase type 6; Oxidative 3-alpha hydroxysteroid dehydrogenase; oxidative 3-alpha-hydroxysteroid-dehydrogenase; oxidoreductase; retinol dehydrogenase; Short chain dehydrogenase/reductase family 9C member 6; short chain dehydrogenase/reductase family 9C, member 6
Gene Aliases: 17betaHSD9; Gm182; HSD17B6; Hsd17b9; HSE; Rdh8; RODH; SDR9C6
UniProt ID: (Human) O14756, (Rat) O54753, (Mouse) Q9R092
Entrez Gene ID: (Human) 8630, (Rat) 286964, (Mouse) 27400
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