|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 1 and 317 of Human HSD17B6|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-28926 targets HSD17B6 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-28926 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 317 of Human HSD17B6.
The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of the retinol dehydrogenase family. Transcript variants utilizing alternative polyadenylation signals exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 17-beta-HSD 6; 17-beta-HSD6; 17-beta-hydroxysteroid dehydrogenase type 6; 3(alpha->beta)-hydroxysteroid epimerase; 3(alpha->beta)-hydroxysteroid epimerasel; 3-alpha->beta-HSE; 3-alpha->beta-hydroxysteroid epimerase; 3-hydroxysteroid epimerase; HSE; hydroxysteroid (17-beta) dehydrogenase 6 homolog; NAD+ -dependent 3 a; NAD+ -dependent 3 alpha-hydroxysteroid dehydrogenase 3-hydroxysteroid epimerase; Oxidative 3-alpha hydroxysteroid dehydrogenase; oxidative 3-alpha-hydroxysteroid-dehydrogenase; oxidoreductase; retinol dehydrogenase; RODH; SDR9C6; Short chain dehydrogenase/reductase family 9C member 6; short chain dehydrogenase/reductase family 9C, member 6
Gene Aliases: HSD17B6; HSE; RODH; SDR9C6
UniProt ID: (Human) O14756
Entrez Gene ID: (Human) 8630
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