Search
Invitrogen
HSD3B1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
PA5-76503
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein of human HSD3B1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
Amyloid beta peptide (Abeta/Beta-amyloid) is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer's disease. Abeta peptide is 40-43 amino acids long and generated from the beta-amyloid precursor protein (beta APP) in a two-step process. The first step involves cleavage of the extracellular, amino-terminal domain of beta APP. Protein cleavage is performed by an aspartyl protease, beta-secretase (BACE) which is synthesized as a propeptide and must be modified to the mature and active form by the prohormone convertase, furin. Beta APP cleavage by the mature form of BACE results in the cellular secretion of a segment of beta APP, and a membrane-bound remnant. The remnant protein is processed by another protease, gamma-secretase. Gamma-secretase cleaves an intra-membrane site in the carboxyl-terminal domain of beta APP, thus generating the amyloid beta peptide. Gamma-secretase is believed to be a multi-subunit complex containing presenilin-1 and 2 as central components. The transmembrane glycoprotein, nicastrin, is associated with presinilins and has been found to bind to the carboxyl-terminus of beta APP and helps to modulate the production of the amyloid beta peptide. Abeta is an extracellular filamentous protein component of amyloid cores, neuritic plaques and is also found as a deposit in neurofibrillary tangles. Alzheimer's disease, the most common cause of senile dementia, is characterized by abnormal filamentous protein deposits in the brain. Beta amyloid deposits are also detected in Lewy body dementia, Down's syndrome, amyloidosis (Dutch type), cerebroarterial amyloidosis (cerebral amyloid angiopathy) and in the Guam Parkinson-Dementia complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: 3 beta-hydroxy-5-ene steroid dehydrogenase; 3 beta-hydroxysteroid dehydrogenase 1; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I; 3-beta-HSD I; 3-beta-hydroxy-5-ene steroid dehydrogenase; 3-beta-hydroxy-Delta(5)-steroid dehydrogenase; 3-beta-hydroxysteroid 3-dehydrogenase; 3-beta-hydroxysteroid dehydrogenase/5-4-isomerase; Delta-5-3-ketosteroid isomerase; Dihydrotestosterone oxidoreductase; HGNC:5217; hydroxysteroid dehydrogenase-1, delta<5>-3-beta; progesterone reductase; short chain dehydrogenase/reductase family 11E, member 1; Steroid Delta-isomerase; Trophoblast antigen FDO161G; unnamed protein product
Gene Aliases: 3-beta-HSD I; 3BETAHSD; 3BH; D3Ertd383e; HSD3B; HSD3B1; HSDB3; HSDB3A; SDR11E1
UniProt ID: (Human) P14060, (Rat) P22071, (Mouse) P24815
Entrez Gene ID: (Human) 3283, (Rat) 360348, (Mouse) 15492
3-keto sterol reductase activity
catalytic activity
3-beta-hydroxy-delta5-steroid dehydrogenase activity
steroid delta-isomerase activity
protein binding
oxidoreductase activity
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
isomerase activity
5-alpha-androstane-3-beta,17-beta-diol dehydrogenase (NADP+) activity
steroid binding
dihydrotestosterone 17-beta-dehydrogenase activity
NAD binding
dehydratase
lipid metabolic process
steroid biosynthetic process
progesterone biosynthetic process
androgen biosynthetic process
estrogen biosynthetic process
steroid metabolic process
C21-steroid hormone metabolic process
organic acid metabolic process
male gonad development
female gonad development
response to herbicide
response to organic substance
response to metal ion
response to lithium ion
response to lead ion
response to organic cyclic compound
response to activity
diterpenoid metabolic process
insecticide metabolic process
biphenyl metabolic process
dibenzo-p-dioxin metabolic process
phenol-containing compound metabolic process
toluene metabolic process
hippocampus development
adrenal gland development
ovulation
granulocyte differentiation
response to nutrient levels
response to estradiol
cellular response to insulin stimulus
response to vitamin E
Leydig cell differentiation
response to L-ascorbic acid
response to drug
response to alkaloid
cellular response to fibroblast growth factor stimulus
response to ethanol
phosphatidylcholine metabolic process
response to arsenic-containing substance
response to cadmium ion
response to corticosterone
response to calcium ion
oxidation-reduction process
maternal process involved in female pregnancy
response to fungicide
testosterone biosynthetic process
cellular response to hydrogen peroxide
response to fatty acid
cellular response to antibiotic
cellular response to mercury ion
cellular response to cAMP
cellular response to glucose stimulus
cellular response to gonadotropin stimulus
cellular response to follicle-stimulating hormone stimulus
cellular response to luteinizing hormone stimulus
cellular response to methylmercury
cellular response to dexamethasone stimulus
cellular response to transforming growth factor beta stimulus
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support