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Invitrogen
HSP20 Monoclonal Antibody (C9)
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FIGURE: 1 / 4
HSP20 Antibody (MA5-41601) in IHC (P)
Immunohistochemistry (Paraffin) analysis of HSP20 in rat cardiac muscle tissue using HSP20 Monoclonal Antibody (C9) (Product # MA5-41601) (20 µg/mL). The sample was then stained with HRP-Goat anti-Mouse IgG polyclonal secondary antibody (2 µg/mL). DAB staining.
Product Details
MA5-41601
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
C9
Immunogen
Recombinant protein Heat Shock Protein Beta 6. The antigen corresponds to amino acid range 1-162 of the target protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
200 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Heat Shock Protein 20 (HSP20), encoded by the HSPB6 gene, is a member of the small heat shock protein (sHSP) family, prominently involved in cellular stress response and maintenance of cytoskeletal integrity. HSP20 is ubiquitously expressed across various tissues, including cardiac and smooth muscle, where its roles are vital in modulating stress resilience and muscle function. It exerts protective effects against apoptosis and oxidative stress by interacting with cell signaling pathways that enhance cellular survival and protein stabilization. In cardiac muscle, HSP20 is known for its cardioprotective actions during ischemic injury, helping preserve myocardial function by inhibiting hypertrophic signaling pathways and promoting muscle relaxation. Studies highlight its involvement in vasodilation processes, as HSP20 interacts with myosin to regulate smooth muscle contraction and dilatation. Beyond its role in muscle physiology, HSP20 has been investigated for its potential therapeutic applications in cardiovascular diseases and metabolic disorders, where its expression and function could be pivotal in disease modulation and treatment strategies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Heat shock 20 kDa-like protein p20; heat shock 20-kDa protein; Heat shock protein; Heat shock protein beta-6; HSP; Hsp20; HspB6
Gene Aliases: Hsp20; Hspb6; p20
UniProt ID: (Rat) P97541
Entrez Gene ID: (Rat) 192245
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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