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Proteintech

HSP70 Polyclonal Antibody

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View all (60) HSP70 antibodies

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HSP70 Polyclonal Antibody

Product Details

10995-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:4,000
View 163 publications 163 publications

Immunohistochemistry (IHC)

-
View 7 publications 7 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500
-

Immunocytochemistry (ICC/IF)

1:20-1:200
View 15 publications 15 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells
View 1 publication 1 publication

ELISA (ELISA)

-
View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg
View 3 publications 3 publications

Miscellaneous PubMed (Misc)

-
View 1 publication 1 publication

Not applicable (N/A)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mollusc, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

HSP70 Fusion Protein Ag1446 (291-641 aa encoded by BC009322)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody well recognized the endogenous HSP70 protein in multiple cell lines.

Immunogen sequence: IDFYTSITR ARFEELCSDL FRSTLEPVEK ALRDAKLDKA QIHDLVLVGG STRIPKVQKL LQDFFNGRDL NKSINPDEAV AYGAAVQAAI LMGDKSENVQ DLLLLDVAPL SLGLETAGGV MTALIKRNST IPTKQTQIFT TYSDNQPGVL IQVYEGERAM TKDNNLLGRF ELSGIPPAPR GVPQIEVTFD IDANGILNVT ATDKSTGKAN KITITNDKGR LSKEEIERMV QEAEKYKAED EVQRERVSAK NALESYAFNM KSAVEDEGLK GKISEADKKK VLDKCQEVIS WLDANTLAEK DEFEHKRKEL EQVCNPIISG LYQGAGGPGP GGFGAQGPKG GSGSGPTIEE VD (291-641 aa encoded by BC009322)

Target Information

HSP70 is a Heat shock protein (HSP) which are expressed in response to various biological stresses, including high temperatures. There are several major families of HSPs that include HSP70, there are HSP90 and HSP100. The HSP70 family is a set of highly conserved proteins that are induced by a variety of biological stresses, including heat stress, in every organism in which the proteins have been examined. The human HSP70 family members include: HSP70, a protein which is strongly inducible in all organisms but which is also constitutively expressed in primate cells; HSP72, a 72 kDa protein that is induced exclusively under stress conditions; HSC70, or cognate protein, is a 72 kDa, constitutively expressed, protein which is involved in the uncoating of clathrin coated vesicles; GRP78, or BiP, is a glucose regulated 78 kDa protein localized in the endoplasmic reticulum; and p75, or HSP75, a 75 kDa protein that is found within the mitochondria. Further, HSP70 is encoded by an intronless gene and, in conjunction with other heat shock proteins, HSP70 stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and organelles. HSP70 is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The HSP70 gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: 68 kDa heat shock protein; 70 kilodalton heat shock protein; dnaK-type molecular chaperone HSP70-1; epididymis secretory protein Li 103; epididymis secretory sperm binding protein; epididymis secretory sperm binding protein Li 5a; heat shock 10kDa protein 1-like; Heat shock 70 kDa protein 1; Heat shock 70 kDa protein 1-Hom; Heat shock 70 kDa protein 1-like; heat shock 70 kDa protein 1/2; Heat shock 70 kDa protein 1A; heat shock 70 kDa protein 1A/1B; Heat shock 70 kDa protein 1B; Heat shock 70 kDa protein 1L; Heat shock 70 kDa protein 2; Heat shock 70 kDa protein 3; Heat shock 70 kDa protein 4; Heat shock 70 kDa-like protein 1; Heat shock 70-related protein APG-2; heat shock 70kD protein 1A; heat shock 70kD protein 1B; heat shock 70kD protein 2; heat shock 70kD protein 4; heat shock 70kD protein-like 1; heat shock 70kDa protein 1-like; heat shock 70kDa protein 1A; heat shock 70kDa protein 1B; heat shock 70kDa protein 2; Heat shock protein; heat shock protein 70-1; Heat shock protein 70-1l; heat shock protein 70.1; Heat shock protein 70.2; heat shock protein alpha 2; heat shock protein cognate 70, testis; Heat shock protein family A member 1A; Heat shock protein family A member 1B; Heat shock protein family A member 1L; Heat shock protein family A member 2; Heat shock protein family H member 2; heat shock protein, 110 kDa; heat shock protein, 70 kDa 1; heat shock protein, 70 kDa 2; heat shock protein, 70 kDa 3; heat shock-induced protein; Heat shock-related 70 kDa protein 2; heat shock-related protein hsc70t; HEL S 103; HSP; Hsp68; HSP70 1; HSP70 1B; HSP70 2; HSP70 AceyltK77; hsp70 RY; HSP70-1; HSP70-1/HSP70-2; HSP70-2; HSP70-Hom; HSP70.1; HSP70.1/2; HSP70.1/HSP70.2; HSP70.3; HSP70RY; HSPA2; HSPA4; Hspa70; HST; inducible heat shock protein 70; Ischemia responsive 94 kDa protein; Spermatid-specific heat shock protein 70; Testis-specific heat shock protein-related; testis-specific heat shock protein-related gene hst70; unnamed protein product

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Gene Aliases: 70kDa; AI317151; APG-2; APG2; Hcp70.1; Hcp70.2; HEL-S-103; HEL-S-5a; HS24/P52; Hsc70t; Hsp110; hsp68; HSP70; HSP70-1; HSP70-1A; HSP70-1B; HSP70-1L; HSP70-2; HSP70-3; HSP70-HOM; HSP70.1; HSP70.2; Hsp70.3; Hsp70A1; HSP70A2; HSP70I; Hsp70RY; HSP70T; HSP72; HSPA1; HSPA1A; HSPA1B; HSPA1L; HSPA2; HSPA4; HSPH2; Hspt70; Hst70; HSX70; hum70t; Irp94; mKIAA4025; Msh5; RY

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UniProt ID: (Human) P0DMV8, (Human) P34931, (Human) P54652, (Human) P34932, (Mouse) Q61696, (Rat) P0DMW0, (Mouse) P17879, (Rat) P55063, (Mouse) P16627, (Rat) P14659, (Mouse) P17156, (Rat) O88600

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Entrez Gene ID: (Human) 3303, (Human) 3304, (Human) 3305, (Human) 3306, (Human) 3308, (Mouse) 193740, (Rat) 24472, (Rat) 294254, (Mouse) 15511, (Rat) 24963, (Mouse) 15482, (Rat) 60460, (Mouse) 15512, (Mouse) 15525, (Rat) 266759

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Function(s)
nucleotide binding virus receptor activity G-protein coupled receptor binding transcription corepressor activity RNA binding receptor binding protein binding ATP binding ATPase activity enzyme binding heat shock protein binding denatured protein binding ubiquitin protein ligase binding death receptor agonist activity histone deacetylase binding protein binding involved in protein folding cadherin binding receptor agonist activity unfolded protein binding misfolded protein binding C3HC4-type RING finger domain binding disordered domain specific binding transcription regulator inhibitor activity ATP-dependent protein disaggregase activity ATP-dependent protein folding chaperone tau protein binding chaperone binding glycolipid binding adenyl-nucleotide exchange factor activity protease binding double-stranded RNA binding ATPase activity, coupled poly(A) RNA binding protein N-terminus binding NF-kappaB binding molecular_function RNA polymerase II transcription factor binding protein complex binding activating transcription factor binding
Process(es)
binding of sperm to zona pellucida biological_process protein refolding negative regulation of transcription from RNA polymerase II promoter mRNA catabolic process protein folding response to unfolded protein lysosomal transport negative regulation of cell proliferation positive regulation of gene expression negative regulation of cell growth negative regulation of transforming growth factor beta receptor signaling pathway endoplasmic reticulum unfolded protein response regulation of protein ubiquitination negative regulation of protein ubiquitination positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of interleukin-8 production positive regulation of RNA splicing cellular response to oxidative stress cellular response to heat cellular response to unfolded protein negative regulation of apoptotic process positive regulation of erythrocyte differentiation ATP metabolic process viral entry into host cell protein stabilization positive regulation of NF-kappaB transcription factor activity chaperone-mediated protein complex assembly cellular heat acclimation positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway cellular response to steroid hormone stimulus positive regulation of microtubule nucleation negative regulation of inclusion body assembly negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway regulation of mitotic spindle assembly negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of tumor necrosis factor-mediated signaling pathway negative regulation of extrinsic apoptotic signaling pathway in absence of ligand telomere maintenance DNA repair response to heat male meiosis male meiosis I spermatogenesis spermatid development response to cold positive regulation of G2/M transition of mitotic cell cycle cell differentiation synaptonemal complex disassembly negative regulation of protein phosphorylation negative regulation of gene expression positive regulation of protein binding negative regulation of DNA binding protein import into mitochondrial outer membrane negative regulation of cell death protein import into mitochondrial matrix response to ischemia response to radiation response to mechanical stimulus regulation of cell death neuron differentiation response to ethanol positive regulation of neuron differentiation kidney development positive regulation of angiogenesis positive regulation of protein phosphorylation multicellular organism development positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle positive regulation of T cell mediated cytotoxicity defense response negative regulation of myeloid cell apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of vasoconstriction response to stress positive regulation of protein targeting to mitochondrion
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