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HSP90 alpha Polyclonal Antibody

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HSP90 alpha Polyclonal Antibody

Product Details

600-401-929

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,500
-

Immunohistochemistry (IHC)

Assay-dependent
-

ELISA (ELISA)

1:5,000-1:25,000
-
Product Specifications

Species Reactivity

Chicken, Fruit fly, Human, Mouse, Non-human primate, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 289-300 of human Hsp90 protein.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.24 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

0.02M potassium phosphate, pH 7.2, with 0.15M NaCl

Contains

0.01% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

This affinity-purified antibody is directed against human Hsp90 protein. A BLAST analysis was used to suggest cross reactivity with Hsp90 from human, mouse, rat, monkey, chicken and Drosophila based on 100% homology with the immunizing sequence. Reactivity of this antibody with Hsp90 from other species is unknown.

Target Information

Heat shock proteins (HSP) are proteins that are expressed in response to various biological stress, including heat. HSP90 is a 90 kDa protein that is induced under stress conditions, but is also one of the most abundant cellular proteins found under non-stress conditions. HSP90 has been found to be associated with a number of other intracellular proteins, including steroid receptors, actin, tubulin, and some kinases. It has been suggested that HSP90 is necessary to maintain structural integrity of at least some steroid receptors to allow for ligand binding during receptor activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: epididymis luminal secretory protein 52; epididymis secretory sperm binding protein Li 65p; Heat shock 86 kDa; heat shock 90kD protein 1, alpha; heat shock 90kD protein 1, alpha-like 4; heat shock 90kD protein, alpha-like 4; heat shock 90kDa protein 1, alpha; Heat shock protein; heat shock protein 1, alpha; heat shock protein 86; heat shock protein 90kDa alpha (cytosolic), class A member 1; heat shock protein 90kDa alpha family class A member 1; Heat shock protein family C member 1; Heat shock protein HSP 90-alpha; heat shock protein HSP90 alpha; heat shock protein, 1; heat shock protein, 86 kDa 1; heat shock protein, 89 kDa; Heat shock protein90; HSP; HSP 86; HSP 90 alpha; HSP86; LAP-2; Lipopolysaccharide-associated protein 2; LPS-associated protein 2; Renal carcinoma antigen NY-REN-38; TSTA; Tumor-specific transplantation 86 kDa antigen; unnamed protein product

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Gene Aliases: 86kDa; 89kDa; AL024080; AL024147; EL52; HEL-S-65p; Hsp103; hsp4; HSP86; Hsp86-1; Hsp89; HSP89A; Hsp90; HSP90A; HSP90AA1; HSP90N; HSPC1; HSPCA; HSPCAL1; HSPCAL4; HSPN; LAP-2; LAP2

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UniProt ID: (Chicken) P11501, (Human) P07900, (Mouse) P07901, (Rat) P82995

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Entrez Gene ID: (Chicken) 423463, (Human) 3320, (Mouse) 15519, (Rat) 299331

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Function(s)
ATP binding protein C-terminus binding ATPase activity nitric-oxide synthase regulator activity estrogen receptor binding TPR domain binding heat shock protein binding progesterone receptor binding identical protein binding virion binding unfolded protein binding chaperone binding Hsp90 protein binding disordered domain specific binding nucleotide binding UTP binding CTP binding RNA binding mRNA binding protein binding GTP binding hydrolase activity sulfonylurea receptor binding protein phosphatase binding MHC class II protein complex binding ubiquitin protein ligase binding dATP binding protein homodimerization activity histone deacetylase binding protein binding involved in protein folding ion channel binding tau protein binding GTPase binding Rho GDP-dissociation inhibitor binding DNA polymerase binding scaffold protein binding ATP-dependent protein folding chaperone enzyme-substrate adaptor activity protein tyrosine kinase binding protein kinase binding poly(A) RNA binding Hsp90 family chaperone
Process(es)
protein folding positive regulation of cell proliferation response to heat response to cold response to organonitrogen compound response to organic cyclic compound response to progesterone cellular response to heat positive regulation of nitric oxide biosynthetic process response to antibiotic regulation of catalytic activity protein stabilization positive regulation of cell cycle G2/M phase transition neuron migration activation of innate immune response positive regulation of defense response to virus by host skeletal muscle contraction mitochondrial transport response to unfolded protein telomere maintenance via telomerase response to xenobiotic stimulus response to salt stress positive regulation of lamellipodium assembly cardiac muscle cell apoptotic process protein import into mitochondrial matrix regulation of protein ubiquitination positive regulation of telomere maintenance via telomerase positive regulation of protein polymerization positive regulation of interferon-beta production regulation of protein localization protein refolding response to cocaine positive regulation of protein import into nucleus regulation of apoptotic process regulation of protein complex assembly protein unfolding response to estrogen positive regulation of protein catabolic process positive regulation of cell size nitric oxide metabolic process chaperone-mediated protein complex assembly positive regulation of cardiac muscle contraction chaperone-mediated autophagy cellular response to virus regulation of postsynaptic membrane neurotransmitter receptor levels neurofibrillary tangle assembly telomerase holoenzyme complex assembly nitric oxide biosynthetic process response to stress positive regulation of protein import into nucleus, translocation protein import into mitochondrial outer membrane positive regulation of cytotoxic T cell differentiation
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