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Invitrogen

HSP90 beta Polyclonal Antibody

View all (43) HSP90 beta antibodies

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Product Details

PA5-27410

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-
Product Specifications

Species Reactivity

Fruit fly, Human, Mouse, Rat, Zebrafish

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of human HSP90 beta. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

5.43 mg/mL

Amount

543 µg

Purification

Protein A

Storage buffer

0.1M tris glycine, pH 7, with 10% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2544886

Product Specific Information

Recommended positive controls: HeLaS3, Neuro2A, C8D30, NIH-3T3, Raw264.7, C2C12, PC-12, Rat-2.

Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (92%), Xenopus laevis (95%), Pig (100%), Chicken (96%), Rhesus Monkey (100%), Chimpanzee (99%), Bovine (100%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Heat shock proteins (HSP) are expressed in response to various biological stresses, including heat. HSP90 is a 90 kDa protein that is induced under stress conditions, but is also one of the most abundant cellular proteins found under non-stress conditions. HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. HSP90 has been found to be associated with a number of other intracellular proteins, including steroid receptors, actin, tubulin, aryl hydrocarbon (Ah) receptor, and some kinases.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 90kDa heat shock protein; AT20544p; CG1242-PA; CG1242-PB; enhancer of seven in absentia 2; enhancer of sevenless 3A; Heat shock 84 kDa; heat shock 90kD protein 1, beta; heat shock 90kDa protein 1, beta; Heat shock protein; heat shock protein 1, beta; Heat shock protein 83; heat shock protein 90 kDa; heat shock protein 90-beta; heat shock protein 90kDa alpha (cytosolic), class B member 1; heat shock protein 90kDa alpha family class B member 1; heat shock protein 90kDa alpha, class B member 1; Heat shock protein family C member 3; Heat shock protein HSP 90-beta; heat shock protein, 84 kDa 1; heat-shock protein 90 kDa; HSP; HSP 82; HSP 84; HSP 90; hsp83; Hsp83-PA; Hsp83-PB; HSP84; HSP90-beta; retinal degeneration slow protein; RP1-302G2.1; scratch; TSTA; Tumor-specific transplantation 84 kDa antigen; unnamed protein product

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Gene Aliases: 143198_at; 83; 83K HSP; 90kDa; AL022974; anon-EST:Liang-2.53; anon-WO0068693; anon-WO0140519.209; C81438; CG1242; clone 2.53; D6S182; Dmel\CG1242; Dmel_CG1242; DMHSP82; DmHsp83; E(sev)3A; E(sina)2; en(lz)3C/4C; HSP82; HSP83; HSP84; Hsp84-1; HSP90; HSP90-BETA; HSP90A1; HSP90AB1; HSP90B; hsp90beta; HSPC2; HSPC3; HSPCB; l(3)j5C2; ms(3)08445; ORF1; P02828; stc; Su(Raf)3A; wu:fa29f01; wu:fa91e11; wu:fd59e11; wu:gcd22h07

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UniProt ID: (Human) P08238, (Fruit fly) P92174, (Mouse) P11499, (Rat) P34058, (Zebrafish) O57521

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Entrez Gene ID: (Human) 3326, (Fruit fly) 38389, (Mouse) 15516, (Rat) 301252, (Zebrafish) 30573

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Function(s)
nucleotide binding RNA binding double-stranded RNA binding protein binding ATP binding ATPase activity protein kinase regulator activity kinase binding protein kinase binding MHC class II protein complex binding nitric-oxide synthase regulator activity TPR domain binding heat shock protein binding ubiquitin protein ligase binding peptide binding identical protein binding protein homodimerization activity histone deacetylase binding ATP-dependent protein binding protein binding involved in protein folding cadherin binding protein dimerization activity tau protein binding unfolded protein binding DNA polymerase binding protein phosphatase activator activity disordered domain specific binding ATP-dependent protein folding chaperone receptor ligand inhibitor activity histone methyltransferase binding insulin receptor binding UTP binding CTP binding GTP binding sulfonylurea receptor binding dATP binding ion channel binding poly(A) RNA binding Hsp90 family chaperone
Process(es)
placenta development protein folding response to unfolded protein telomere maintenance via telomerase virion attachment to host cell positive regulation of transforming growth factor beta receptor signaling pathway regulation of protein ubiquitination negative regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of protein localization cellular response to heat negative regulation of apoptotic process positive regulation of nitric oxide biosynthetic process positive regulation of cell differentiation protein stabilization chaperone-mediated protein complex assembly regulation of cell cycle cellular response to interleukin-4 fibril organization negative regulation of proteasomal protein catabolic process telomerase holoenzyme complex assembly positive regulation of protein localization to cell surface positive regulation of neuroblast proliferation centrosome cycle negative regulation of cell proliferation response to heat cold acclimation negative regulation of transposition pole plasm mRNA localization proteasome assembly regulation of circadian sleep/wake cycle, sleep positive regulation of insulin receptor signaling pathway oogenesis response to stress positive regulation of protein binding positive regulation of protein import into nucleus, translocation negative regulation of neuron apoptotic process positive regulation of cell size positive regulation of protein serine/threonine kinase activity response to salt stress regulation of interferon-gamma-mediated signaling pathway regulation of type I interferon-mediated signaling pathway cellular response to organic cyclic compound blood vessel development muscle organ development response to estrogen leukocyte migration negative regulation of cell cycle arrest negative regulation of transforming growth factor beta activation
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