Proteintech

HSP90AB1 Polyclonal Antibody

HSP90AB1 Antibody in Immunocytochemistry (ICC/IF)

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HSP90AB1 Antibody (11405-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using HSP90AB1 antibody 11405-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

HSP90AB1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

HSP90AB1 Antibody in Flow Cytometry (Flow)

HSP90AB1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

11405-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:2,000-1:10,000

View 22 publications 22 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:250-1:1,000

Immunocytochemistry (ICC/IF)

1:10-1:100

View 1 publication 1 publication

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Immunoprecipitation (IP)

0.5-4.0 µg

View 4 publications 4 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Deer, Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

HSP90AB1 Fusion Protein Ag1947 (330-710 aa encoded by BC014485)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: RALLFIPRR APFDLFENKK KKNNIKLYVR RVFIMDSCDE LIPEYLNFIR GVVDSEDLPL NISREMLQQS KILKVIRKNI VKKCLELFSE LAEDKENYKK FYEAFSKNLK LGIHEDSTNR RRLSELLRYH TSQSGDEMTS LSEYVSRMKE TQKSIYYITG ESKEQVANSA FVERVRKRGF EVVYMTEPID EYCVQQLKEF DGKSLVSVTK EGLELPEDEE EKKKMEESKA KFENLCKLMK EILDKKVEKV TISNRLVSSP CCIVTSTYGW TANMERIMKA QALRDNSTMG YMMAKKHLEI NPDHPIVETL RQKAEADKND KAVKDLVVLL FETALLSSGF SLEDPQTHSN RIYRMIKLGL GIDEDEVAAE EPNAAVPDEI PP (330-710 aa encoded by BC014485)

Target Information

Heat shock proteins (HSP) are expressed in response to various biological stresses, including heat. HSP90 is a 90 kDa protein that is induced under stress conditions, but is also one of the most abundant cellular proteins found under non-stress conditions. HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. HSP90 has been found to be associated with a number of other intracellular proteins, including steroid receptors, actin, tubulin, aryl hydrocarbon (Ah) receptor, and some kinases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Heat shock 84 kDa; heat shock 90kD protein 1, beta; heat shock 90kDa protein 1, beta; Heat shock protein; heat shock protein 1, beta; heat shock protein 90 kDa; heat shock protein 90kDa alpha (cytosolic), class B member 1; heat shock protein 90kDa alpha family class B member 1; Heat shock protein family C member 3; Heat shock protein HSP 90-beta; heat shock protein, 84 kDa 1; HSP; HSP 84; HSP 90; HSP84; HSP90-beta; retinal degeneration slow protein; RP1-302G2.1; TSTA; Tumor-specific transplantation 84 kDa antigen

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Gene Aliases: 90kDa; AL022974; C81438; D6S182; HSP84; Hsp84-1; Hsp90; HSP90-BETA; HSP90AB1; HSP90B; HSPC2; HSPC3; HSPCB

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UniProt ID: (Human) P08238, (Mouse) P11499, (Rat) P34058

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Entrez Gene ID: (Human) 3326, (Mouse) 15516, (Rat) 301252

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Function(s)

UTP binding CTP binding double-stranded RNA binding protein binding ATP binding GTP binding sulfonylurea receptor binding protein kinase regulator activity kinase binding protein kinase binding MHC class II protein complex binding nitric-oxide synthase regulator activity TPR domain binding dATP binding histone deacetylase binding ion channel binding poly(A) RNA binding unfolded protein binding cadherin binding involved in cell-cell adhesion nucleotide binding Hsp90 family chaperone

Process(es)

placenta development protein folding response to unfolded protein response to salt stress virion attachment to host cell regulation of protein ubiquitination positive regulation of protein binding negative regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of phosphoprotein phosphatase activity positive regulation of protein import into nucleus, translocation Fc-gamma receptor signaling pathway involved in phagocytosis negative regulation of neuron apoptotic process positive regulation of nitric oxide biosynthetic process positive regulation of cell size protein stabilization regulation of interferon-gamma-mediated signaling pathway regulation of type I interferon-mediated signaling pathway cellular response to interleukin-4 cellular response to organic cyclic compound positive regulation of protein serine/threonine kinase activity fibril organization cell-cell adhesion regulation of cellular response to heat response to stress

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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HSP90AB1 Polyclonal Antibody

HSP90AB1 Antibody (11405-1-AP) in ICC/IF

Product Details

11405-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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