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Proteintech
HSP90AB1 Polyclonal Antibody
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Product Details
11405-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Deer,
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HSP90AB1 Fusion Protein Ag1947 (330-710 aa encoded by BC014485)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: RALLFIPRR APFDLFENKK KKNNIKLYVR RVFIMDSCDE LIPEYLNFIR GVVDSEDLPL NISREMLQQS KILKVIRKNI VKKCLELFSE LAEDKENYKK FYEAFSKNLK LGIHEDSTNR RRLSELLRYH TSQSGDEMTS LSEYVSRMKE TQKSIYYITG ESKEQVANSA FVERVRKRGF EVVYMTEPID EYCVQQLKEF DGKSLVSVTK EGLELPEDEE EKKKMEESKA KFENLCKLMK EILDKKVEKV TISNRLVSSP CCIVTSTYGW TANMERIMKA QALRDNSTMG YMMAKKHLEI NPDHPIVETL RQKAEADKND KAVKDLVVLL FETALLSSGF SLEDPQTHSN RIYRMIKLGL GIDEDEVAAE EPNAAVPDEI PP (330-710 aa encoded by BC014485)
Target Information
Heat shock proteins (HSP) are expressed in response to various biological stresses, including heat. HSP90 is a 90 kDa protein that is induced under stress conditions, but is also one of the most abundant cellular proteins found under non-stress conditions. HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. HSP90 has been found to be associated with a number of other intracellular proteins, including steroid receptors, actin, tubulin, aryl hydrocarbon (Ah) receptor, and some kinases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Heat shock 84 kDa; heat shock 90kD protein 1, beta; heat shock 90kDa protein 1, beta; Heat shock protein; heat shock protein 1, beta; heat shock protein 90 kDa; heat shock protein 90kDa alpha (cytosolic), class B member 1; heat shock protein 90kDa alpha family class B member 1; Heat shock protein family C member 3; Heat shock protein HSP 90-beta; heat shock protein, 84 kDa 1; HSP; HSP 84; HSP 90; HSP84; HSP90-beta; retinal degeneration slow protein; RP1-302G2.1; TSTA; Tumor-specific transplantation 84 kDa antigen
Gene Aliases: 90kDa; AL022974; C81438; D6S182; HSP84; Hsp84-1; Hsp90; HSP90-BETA; HSP90AB1; HSP90B; HSPC2; HSPC3; HSPCB
UniProt ID: (Human) P08238, (Mouse) P11499, (Rat) P34058
Entrez Gene ID: (Human) 3326, (Mouse) 15516, (Rat) 301252
UTP binding
CTP binding
double-stranded RNA binding
protein binding
ATP binding
GTP binding
sulfonylurea receptor binding
protein kinase regulator activity
kinase binding
protein kinase binding
MHC class II protein complex binding
nitric-oxide synthase regulator activity
TPR domain binding
dATP binding
histone deacetylase binding
ion channel binding
poly(A) RNA binding
unfolded protein binding
cadherin binding involved in cell-cell adhesion
nucleotide binding
Hsp90 family chaperone
placenta development
protein folding
response to unfolded protein
response to salt stress
virion attachment to host cell
regulation of protein ubiquitination
positive regulation of protein binding
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of phosphoprotein phosphatase activity
positive regulation of protein import into nucleus, translocation
Fc-gamma receptor signaling pathway involved in phagocytosis
negative regulation of neuron apoptotic process
positive regulation of nitric oxide biosynthetic process
positive regulation of cell size
protein stabilization
regulation of interferon-gamma-mediated signaling pathway
regulation of type I interferon-mediated signaling pathway
cellular response to interleukin-4
cellular response to organic cyclic compound
positive regulation of protein serine/threonine kinase activity
fibril organization
cell-cell adhesion
regulation of cellular response to heat
response to stress
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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