This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 83%
HSPB7 encodes a small heat shock family B member that can heterodimerize with similar heat shock proteins. Defects in this gene are associated with advanced heart failure. In addition, the encoded protein may be a tumor suppressor in the p53 pathway, with defects in this gene being associated with renal cell carcinoma.
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Protein Aliases: Cardiovascular heat shock protein; CVHSP; heat shock 27kD protein family member 7; heat shock 27kD protein family, member 7 (cardiovascular); heat shock 27kDa protein family member 7 (cardiovascular); heat shock 27kDa protein family, member 7 (cardiovascular); Heat shock protein 25 kDa 2; heat shock protein 25 kDa 2 (cardiovascular); Heat shock protein beta-7; heat shock protein family, alpha-crystallin-related, b7; heat shock protein family, member 7 (cardiovascular); HspB7; Protein p19/6.8
Gene Aliases: 27kDa; CVHSP; Hsp25-2; HSPB7; zgc:103426
Molecular Function: chaperone