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Product Details
13383-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HSPH1 Fusion Protein Ag4224 (508-858 aa encoded by BC037553)
Conjugate
Form
Liquid
Concentration
0.39 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody recognizes both HSP105alpha and HSP105beta isoforms. Western blot analysis using this antibody detected a major band around 100-110kD in Jurkat cells.
Immunogen sequence: MSSEADMEC LNQRPPENPD TDKNVQQDNS EAGTQPQVQT DAQQTSQSPP SPELTSEENK IPDADKANEK KVDQPPEAKK PKIKVVNVEL PIEANLVWQL GKDLLNMYIE TEGKMIMQDK LEKERNDAKN AVEEYVYEFR DKLCGPYEKF ICEQDHQNFL RLLTETEDWL YEEGEDQAKQ AYVDKLEELM KIGTPVKVRF QEAEERPKMF EELGQRLQHY AKIAADFRNK DEKYNHIDES EMKKVEKSVN EVMEWMNNVM NAQAKKSLDQ DPVVRAQEIK TKIKELNNTC EPVVTQPKPK IESPKLERTP NGPNIDKKEE DLEDKNNFGA EPPHQNGECY PNEKNSVNMD LD (508-858 aa encoded by BC037553)
Target Information
HSPH1 prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. This protein inhibits HSPA8/HSC70 ATPase and chaperone activities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Antigen NY-CO-25; heat shock 105kD alpha; heat shock 105kD beta; heat shock 105kDa/110kDa protein 1; Heat shock 110 kDa protein; Heat shock protein; Heat shock protein 105 kDa; Heat shock protein family H member 1; HSP; NY CO 25
Gene Aliases: HSP105; HSP105A; HSP105B; HSP110; HSPH1; KIAA0201; NY-CO-25
UniProt ID: (Human) Q92598
Entrez Gene ID: (Human) 10808
receptor-mediated endocytosis
response to unfolded protein
positive regulation of MHC class I biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
chaperone mediated protein folding requiring cofactor
positive regulation of NK T cell activation
positive regulation of protein tyrosine kinase activity
regulation of cellular response to heat
negative regulation of establishment of protein localization to mitochondrion
negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
negative regulation of p38MAPK cascade
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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