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Proteintech
HTR1B Polyclonal Antibody
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Product Details
22189-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HTR1B Fusion Protein Ag16753 (228-315 aa encoded by BC096207)
Conjugate
Form
Liquid
Concentration
0.51 mg/mL
Amount
76.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: YGRIYVEAR SRILKQTPNR TGKRLTRAQL ITDSPGSTSS VTSINSRVPD VPSESGSPVY VNQVKVRVSD ALLEKKKLMA ARERKATKT (228-315 aa encoded by BC096207)
Target Information
Serotonin (5-hydroxytryptamine, 5-HT), originally discovered as a serum factor plays important roles in regulating diverse biological processes in central and peripheral nervous systems, cardiovascular systems, and gastrointestinal systems. Molecular cloning studies have identified 5 receptors belonging to the 5-HT1 subtypes. These receptors are negatively coupled to adenylyl cyclase. Radioligand binding studies suggest the presence of 5-HT1B (formerly known as 5-HT1DbR) sites in substantia nigra, dorsal subiculum, globus pallidus, and superior collicum. In situ hybridization studies show abundance of 5-HT1BR mRNA in CA1 pyramidal cells of hippocampus, Purkinje cells of cerebellum, olfactory tubercle, subthalamic nucleus and somewhat lower levels in the caudate-putamen, cortical areas, thalamic and hypothalamic nuclei.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 5-HT-1B; 5-HT-1D-beta; 5-HT1B receptor; 5-HT<1B> receptor; 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled; 5-hydroxytryptamine receptor 1B; 5HT1B Receptor; S12; Serotonin 1D beta receptor; Serotonin receptor 1B; unnamed protein product
Gene Aliases: 5-HT-1B; 5-HT-1D-beta; 5-HT1B; 5-HT1DB; 5ht1b; HTR1B; HTR1D2; HTR1DB; S12
UniProt ID: (Human) P28222, (Mouse) P28334
Entrez Gene ID: (Human) 3351, (Mouse) 15551
signal transduction
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting serotonin receptor signaling pathway
phospholipase C-activating serotonin receptor signaling pathway
chemical synaptic transmission
negative regulation of serotonin secretion
vasoconstriction
bone remodeling
regulation of behavior
cellular response to alkaloid
cellular response to xenobiotic stimulus
positive regulation of vascular smooth muscle cell proliferation
G-protein coupled receptor internalization
protein kinase C-activating G-protein coupled receptor signaling pathway
serotonin receptor signaling pathway
behavior
feeding behavior
response to toxic substance
regulation of dopamine secretion
negative regulation of cAMP biosynthetic process
negative regulation of synaptic transmission, GABAergic
cellular response to drug
response to cocaine
response to drug
drinking behavior
response to ethanol
negative regulation of synaptic transmission, glutamatergic
cellular response to temperature stimulus
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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