In IHC applications, antigen retrieval using Proteinase K treatment is recommended.
Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Marmoset (100%) Mouse, Rat, Bat, Horse, Pig (94%).
Serotonin (5-hydroxytryptamine, 5-HT), originally discovered as a serum factor plays important roles in regulating diverse biological processes in central and peripheral nervous systems, cardiovascular systems, and gastrointestinal systems. Molecular cloning studies have identified 5 receptors belonging to the 5-HT1 subtypes. These receptors are negatively coupled to adenylyl cyclase. Radioligand binding studies suggest the presence of 5-HT1B (formerly known as 5-HT1DbR) sites in substantia nigra, dorsal subiculum, globus pallidus, and superior collicum. In situ hybridization studies show abundance of 5-HT1BR mRNA in CA1 pyramidal cells of hippocampus, Purkinje cells of cerebellum, olfactory tubercle, subthalamic nucleus and somewhat lower levels in the caudate-putamen, cortical areas, thalamic and hypothalamic nuclei.
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Protein Aliases: 5-HT-1B; 5-HT-1D-beta; 5-HT1B; 5-HT1b receptor; 5-HT1DB; 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled; 5-hydroxytryptamine receptor 1B; 5HT1B Receptor; HTR1B; HTR1D2; HTR1DB; S12; Serotonin 1b receptor; Serotonin 1D beta receptor; Serotonin 5-HT-1b receptor; Serotonin receptor 1B
Gene Aliases: 5-HT-1B; 5-HT-1D-beta; 5-HT1B; 5-HT1DB; HTR1B; HTR1D2; HTR1DB; S12
UniProt ID: (Human) P28222
Entrez Gene ID: (Human) 3351