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Product Details
PA5-120747
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HTR2A (NP_000612.1).
Conjugate
Form
Liquid
Concentration
2.55 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2914319
Product Specific Information
Positive test controls include: SH-SY5Y, Mouse brain.^M
^M
Immunogen sequence: MDILCEENTS LSSTTNSLMQ LNDDTRLYSN DFNSGEANTS DAFNWTVDSE NRTNLSCEGC LSPSCLSLLH LQEKNWSALL TAVVIILTIA GNILVIMAVS
Target Information
In platelets and gut, serotonin plays a major role in cardiovascular function and motility of the gastrointestinal tract, respectively. Serotonin mediates its effects through several of G protein coupled receptors, designated 5-HT receptors or alternatively SR receptors. The SR-2 receptors are comprised of three subtypes, SR-2A, SR-2B and SR-2C, which activate phospholipase C and release intracellular stores of calcium in response to serotonin. SR-2A has a specific role in tracheal smooth muscle contraction, bronchoconstriction and mediating aldosterone production, and it is also thought to play a role in several psychiatric disorders, including depression and schizophrenia. SR-2B is expressed in embryonic and adult cardiovascular tissues, gut and brain and plays an important role in the pathology of cardiac disorders. SR-2C is thought to mediate the effects of atypical antipsychotic drugs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5-HT-2; 5-HT-2A; 5-HT2 receptor; 5-HT2A receptor; 5-HT2A/2C; 5-HT2A/2C receptor; 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled; 5-hydroxytryptamine 2 receptor; 5-hydroxytryptamine receptor 2A; 5HT2A Receptor; serotonin 5-HT-2A receptor; Serotonin receptor 2A; SR2A
Gene Aliases: 5-HT2A; E030013E04; Htr-2; HTR2; HTR2A
UniProt ID: (Human) P28223, (Mouse) P35363
Entrez Gene ID: (Human) 3356, (Mouse) 15558
temperature homeostasis
cellular calcium ion homeostasis
activation of phospholipase C activity
phospholipase C-activating serotonin receptor signaling pathway
serotonin receptor signaling pathway
chemical synaptic transmission
aging
memory
cell death
positive regulation of cell proliferation
positive regulation of phosphatidylinositol biosynthetic process
regulation of dopamine secretion
phosphatidylinositol 3-kinase signaling
artery smooth muscle contraction
urinary bladder smooth muscle contraction
sleep
response to drug
negative regulation of potassium ion transport
positive regulation of MAP kinase activity
protein localization to cytoskeleton
positive regulation of fat cell differentiation
positive regulation of glycolytic process
positive regulation of vasoconstriction
viral entry into host cell
regulation of hormone secretion
behavioral response to cocaine
positive regulation of peptidyl-tyrosine phosphorylation
regulation of behavior
detection of temperature stimulus involved in sensory perception of pain
detection of mechanical stimulus involved in sensory perception of pain
release of sequestered calcium ion into cytosol
negative regulation of synaptic transmission, glutamatergic
positive regulation of ERK1 and ERK2 cascade
smooth muscle contraction
signal transduction
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
behavior
sensory perception of pain
positive regulation of kinase activity
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