Synthetic peptide sequence: 400-431aa, KENKKPLQLILVNTIPALAYKSSQLQMGQKKN.
Reconstitution information: Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
In platelets and gut, serotonin plays a major role in cardiovascular function and motility of the gastrointestinal tract, respectively. Serotonin mediates its effects through several of G protein coupled receptors, designated 5-HT receptors or alternatively SR receptors. The SR-2 receptors are comprised of three subtypes, SR-2A, SR-2B and SR-2C, which activate phospholipase C and release intracellular stores of calcium in response to serotonin. SR-2A has a specific role in tracheal smooth muscle contraction, bronchoconstriction and mediating aldosterone production, and it is also thought to play a role in several psychiatric disorders, including depression and schizophrenia. SR-2B is expressed in embryonic and adult cardiovascular tissues, gut and brain and plays an important role in the pathology of cardiac disorders. SR-2C is thought to mediate the effects of atypical antipsychotic drugs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 5-HT-2; 5-HT-2A; 5-HT2 receptor; 5-HT2A receptor; 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled; 5-hydroxytryptamine 2 receptor; 5-hydroxytryptamine receptor 2A; HTR2; HTR2A; serotonin 5-HT-2A receptor; serotonin 5HT-2 receptor; Serotonin receptor 2A
Gene Aliases: 5-HT2A; 5Ht-2; E030013E04; Htr-2; HTR2; HTR2A