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Proteintech

HTR2B Polyclonal Antibody

2 References
View all (14) HTR2B antibodies
Datasheet
Protocols
Questions & Answers
Tech Support
Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

26408-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
View 1 publication 1 publication

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500
-
Product Specifications

Species Reactivity

Human, Mouse

Published species

Not Applicable

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

HTR2B Fusion Protein Ag24007 (1-56 aa encoded by BC063123)
View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

0.41 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Product Specific Information

Immunogen sequence: MALSYRVSE LQSTIPEHIL QSTFVHVISS NWSGLQTESI PEEMKQIVEE QGNKLHW (1-56 aa encoded by B C063123)

Target Information

HTR2B is a g-protein coupled receptor for 5-hydroxytryptamine (serotonin). It functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. HTR2B also plays a role in perception of pain, regulation of behavior. It is required to normal proliferation of embryonic cardiac myocytes and normal heart development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: 5-HT 2B receptor; 5-HT-2B; 5-HT-2F; 5-HT2b receptor; 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled; 5-hydroxytryptamine 2B receptor; 5-hydroxytryptamine receptor 2B; 5-hydroxytryptamine receptor 2B variant b; 5HT2B Receptor; NP75 protein; Serotonin receptor 2B

Gene Aliases: 5-HT(2B); 5-HT-2B; 5-HT2B; AJ012488; AV377389; HTR2B

UniProt ID: (Human) P41595, (Mouse) Q02152

Entrez Gene ID: (Human) 3357, (Mouse) 15559

Molecular Function: G-protein coupled receptor

Function(s)
neural crest cell migration positive regulation of cytokine production positive regulation of endothelial cell proliferation G-protein coupled receptor internalization heart morphogenesis cardiac muscle hypertrophy cGMP biosynthetic process cellular calcium ion homeostasis G-protein coupled receptor signaling pathway activation of phospholipase C activity protein kinase C-activating G-protein coupled receptor signaling pathway serotonin receptor signaling pathway behavior positive regulation of cell proliferation negative regulation of autophagy positive regulation of phosphatidylinositol biosynthetic process neural crest cell differentiation phosphatidylinositol 3-kinase signaling intestine smooth muscle contraction phosphorylation calcium-mediated signaling hepatic stellate cell activation vasoconstriction response to drug negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAP kinase activity positive regulation of GTPase activity inositol phosphate metabolic process embryonic morphogenesis positive regulation of cytokine secretion regulation of behavior positive regulation of nitric-oxide synthase activity release of sequestered calcium ion into cytosol positive regulation of cell division negative regulation of cell death ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade protein kinase C signaling cellular response to amine stimulus cellular response to temperature stimulus cellular response to serotonin smooth muscle contraction signal transduction phospholipase C-activating serotonin receptor signaling pathway heart development ion transmembrane transport
Process(es)
G-protein alpha-subunit binding G-protein coupled serotonin receptor activity GTPase activator activity drug binding serotonin binding signal transducer activity G-protein coupled receptor activity
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