HTR2B is a g-protein coupled receptor for 5-hydroxytryptamine (serotonin). It functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. HTR2B also plays a role in perception of pain, regulation of behavior. It is required to normal proliferation of embryonic cardiac myocytes and normal heart development.
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Protein Aliases: 5 HT 2B; 5 HT(2B); 5 HT2B; 5-HT 2B receptor; 5-HT-2B; 5-HT-2F; 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled; 5-hydroxytryptamine 2B receptor; 5-hydroxytryptamine receptor 2B; 5-hydroxytryptamine receptor 2B variant b; HTR2B; NP75 protein; Serotonin receptor 2B
Gene Aliases: 5-HT(2B); 5-HT-2B; 5-HT2B; AJ012488; AV377389; HTR2B