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Proteintech

HTR2B Polyclonal Antibody

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HTR2B Polyclonal Antibody

Product Details

26408-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
View 1 publication 1 publication

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500
-
Product Specifications

Species Reactivity

Mouse, Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

HTR2B Fusion Protein Ag24007 (1-56 aa encoded by BC063123)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.41 mg/mL

Amount

61.5 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MALSYRVSE LQSTIPEHIL QSTFVHVISS NWSGLQTESI PEEMKQIVEE QGNKLHW (1-56 aa encoded by B C063123)

Target Information

HTR2B is a g-protein coupled receptor for 5-hydroxytryptamine (serotonin). It functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. HTR2B also plays a role in perception of pain, regulation of behavior. It is required to normal proliferation of embryonic cardiac myocytes and normal heart development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: 5-HT 2B receptor; 5-HT-2B; 5-HT-2F; 5-HT2b receptor; 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled; 5-hydroxytryptamine 2B receptor; 5-hydroxytryptamine receptor 2B; 5HT2B Receptor; NP75 protein; serotonin; Serotonin receptor 2B; unnamed protein product

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Gene Aliases: 5-HT(2B); 5-HT-2B; 5-HT2B; AJ012488; AV377389; HTR2B

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UniProt ID: (Human) P41595, (Mouse) Q02152

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Entrez Gene ID: (Human) 3357, (Mouse) 15559

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Function(s)
Gq/11-coupled serotonin receptor activity G-protein alpha-subunit binding G-protein coupled receptor activity G-protein coupled serotonin receptor activity GTPase activator activity protein binding neurotransmitter receptor activity serotonin binding serotonin receptor activity signal transducer activity drug binding G-protein coupled receptor
Process(es)
neural crest cell migration positive regulation of cytokine production positive regulation of endothelial cell proliferation heart morphogenesis cardiac muscle hypertrophy cellular calcium ion homeostasis smooth muscle contraction signal transduction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger phospholipase C-activating serotonin receptor signaling pathway serotonin receptor signaling pathway chemical synaptic transmission heart development positive regulation of cell proliferation response to xenobiotic stimulus positive regulation of phosphatidylinositol biosynthetic process neural crest cell differentiation intestine smooth muscle contraction calcium-mediated signaling cGMP-mediated signaling vasoconstriction negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling embryonic morphogenesis regulation of behavior release of sequestered calcium ion into cytosol positive regulation of cell division ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade G protein-coupled serotonin receptor signaling pathway G-protein coupled receptor internalization cGMP biosynthetic process activation of phospholipase C activity protein kinase C-activating G-protein coupled receptor signaling pathway behavior negative regulation of autophagy phosphatidylinositol 3-kinase signaling phosphorylation ion transmembrane transport response to drug positive regulation of MAP kinase activity positive regulation of GTPase activity positive regulation of cytokine secretion positive regulation of nitric-oxide synthase activity negative regulation of cell death protein kinase C signaling cellular response to amine stimulus cellular response to temperature stimulus cellular response to serotonin
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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