Peptide sequence: PLWACILVAA GILATDTHHP QDSALYHLSK QLLQKYHKEV RPVYNWTKAT
Sequence homology: Cow: 79%; Dog: 77%; Guinea Pig: 79%; Human: 100%; Mouse: 77%; Pig: 86%; Rabbit: 86%; Rat: 79%
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit B of the type 3 receptor for 5-hydroxytryptamine, a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude.
Protein Aliases: 5-HT3 receptor subunit B; 5-HT3-B; 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic; 5-hydroxytryptamine 3 receptor B subunit; 5-hydroxytryptamine receptor 3B; Serotonin receptor 3B; serotonin-gated ion channel subunit
Gene Aliases: 5-HT3B; HTR3B
Molecular Function: ligand-gated ion channel