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Invitrogen
HTR7 Polyclonal Antibody
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FIGURE: 1 / 4
HTR7 Antibody (PA1-41122) in ICC/IF
Immunofluorescence analysis of HTR7 was performed using 70% confluent log phase differentiated PC-12 cells into neurons. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with HTR7 Polyclonal Antibody (Product # PA1-41122) at 1:100 dilution in 0.1% BSA, incubated at 4 degree Celsius overnight and then labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488... View More
Product Details
PA1-41122
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human,
Mouse,
Rat
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mixture of synthetic peptides corresponding to amino acids 13-28 of the rat 5-HT7R.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with porcine samples based on sequence homology.
The immunogen sequence is 93% conserved with canine 5-HT7Ra/b, and 81% conserved with porcine 5-HT7R.
Target Information
5-HT7 Receptor is a Serotonin Receptor with several functions, including regulation of the circadian rhythm and mediation of smooth-muscle relaxation in the vasculature and GI tract. This receptor has been implicated in depression, autism, and other neuropsychiatric disorders. Three protein isoforms have been documented: isoform a: 445aa; isoform b: 432aa; isoform d: 479aa. 5-HT7 Receptor has been reported in aorta, brain, heart, placenta, small intestine, spleen, artery, and vessel. An EST has been isolated from a testis library.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 5-HT receptor 7a; 5-HT-7; 5-HT-X; 5-HT7; 5-HT7 receptor; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled); 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled; 5-hydroxytryptamine receptor 7; 5HT7 Receptor; GPRFO; high affinity serotonin receptor (5HT7); HT7; OTTHUMP00000020077; OTTHUMP00000020078; OTTHUMP00000020079; Serotonin receptor 7
Gene Aliases: 5-HT7; 5Ht7; HTR7
UniProt ID: (Human) P34969, (Mouse) P32304, (Rat) P32305
Entrez Gene ID: (Human) 3363, (Dog) 477762, (Mouse) 15566, (Rat) 65032
smooth muscle contraction
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
serotonin receptor signaling pathway
chemical synaptic transmission
circadian rhythm
blood circulation
vasoconstriction
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-activating serotonin receptor signaling pathway
memory
positive regulation of neuron projection development
negative regulation of serotonin secretion
urinary bladder smooth muscle contraction
negative regulation of circadian sleep/wake cycle, REM sleep
behavioral response to pain
detection of mechanical stimulus involved in sensory perception of pain
response to corticosterone
micturition
long-term synaptic potentiation
dopaminergic neuron differentiation
response to electrical stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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