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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • HTRA1 Antibodies

          Proteintech

          HTRA1 Polyclonal Antibody

          14 References
          View all (13) HTRA1 antibodies

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          Datasheet
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          Cite HTRA1 Polyclonal Antibody

          • Antibody Testing Data (9)
          HTRA1 Antibody in Immunocytochemistry (ICC/IF)
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          HTRA1 Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          FIGURE: 1 / 9

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          HTRA1 Antibody (55011-1-AP) in ICC/IF

          Immunofluorescent analysis of HepG2 cells using 55011-1-AP (HTRA1 antibody) at dilution of 1:25 and Alexa Fluor 594-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          HTRA1 Antibody in Immunocytochemistry (ICC/IF)
          HTRA1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          HTRA1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          HTRA1 Antibody in Western Blot (WB)
          HTRA1 Antibody in Western Blot (WB)
          HTRA1 Antibody in Western Blot (WB)
          HTRA1 Antibody in Western Blot (WB)
          HTRA1 Antibody in Western Blot (WB)
          HTRA1 Antibody in Immunoprecipitation (IP)

          Product Details

          55011-1-AP

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:2,000
          View 6 publications 6 publications

          Immunohistochemistry (IHC)

          -
          View 4 publications 4 publications

          Immunohistochemistry (Paraffin) (IHC (P))

          1:100-1:400
          -

          Immunocytochemistry (ICC/IF)

          1:10-1:100
          View 3 publications 3 publications

          Immunoprecipitation (IP)

          0.5-4.0 µg
          -

          Not applicable (N/A)

          -
          View 1 publication 1 publication
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Published species

          Human, Mouse, Rat, Zebrafish

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Peptide

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.46 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.3, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Wet ice (domestic); Dry ice (international)

          Product Specific Information

          The 50 kDa HTRA1 was found at varying levels in the majority of samples tested, whereas the 42 kDa form of HTRA1 was identified in degenerated intervertebral disc protein samples. The antibody is specific to HTRA1.

          Target Information

          HtrA1, a 51KDa protein, is a member of highly conserved mammalian HtrA serine protease family. It is a human homolog of bacterial HtrA and consists of a secretory signal sequence, an IGFBP-binding domain and a Kazal-type serine-protease inhibitor domain at the N-terminus and a highly conserved trypsin-like serine/protease domain and a PDZ domain at the C-terminus. It plays a major role in the regulation of cell growth. HtrA1 inhibits signaling mediated by TGF-beta family members and regulates many physiological processes. HtrA1 is up-regulated in placenta during pregnancy and plays an important role in implantation and placental physiology. It regulates the availability of IGFs by cleaving IGF-binding proteins. It acts as a tumor suppressor and is down-regulated in ovarian cancers and melanomas. Its role has been implicated in osteoarthritis suggesting a therapeutic intervention. Northern blot analysis detected high expression in placenta.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: High-temperature requirement A serine peptidase 1; IGFBP5-protease; insulin-like growth factor binding protein 5 protease; L56; protease serine 11; protease, serine, 11 (IGF binding); Serine protease 11; Serine protease HTRA1

          View more View less

          Gene Aliases: AI429470; ARMD7; CADASIL2; CARASIL; HTRA; HTRA1; L56; ORF480; PRSS11; RSPP11

          View more View less

          UniProt ID: (Human) Q92743, (Rat) Q9QZK5, (Mouse) Q9R118

          View more View less

          Entrez Gene ID: (Human) 5654, (Rat) 65164, (Mouse) 56213

          View more View less

          Function(s)
          serine-type endopeptidase activity insulin-like growth factor binding serine-type peptidase activity protein binding peptidase activity hydrolase activity growth factor binding serine protease
          Process(es)
          regulation of cell growth placenta development proteolysis extracellular matrix disassembly negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of BMP signaling pathway positive regulation of epithelial cell proliferation negative regulation of defense response to virus chorionic trophoblast cell differentiation dentinogenesis
          It has to be done as per old AB suggested Products section.
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          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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