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Invitrogen
HTRA1 Polyclonal Antibody
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Product Details
PA5-23395
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Dog,
Human,
Mouse,
Non-human primate,
Rat
Published species
Bovine
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Within the range of amino acids 234-262 of human HtrA1.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum with 50% glycerol
Contains
0.025% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reactive to Chimpanzee.
Target Information
HtrA1, a 51KDa protein, is a member of highly conserved mammalian HtrA serine protease family. It is a human homolog of bacterial HtrA and consists of a secretory signal sequence, an IGFBP-binding domain and a Kazal-type serine-protease inhibitor domain at the N-terminus and a highly conserved trypsin-like serine/protease domain and a PDZ domain at the C-terminus. It plays a major role in the regulation of cell growth. HtrA1 inhibits signaling mediated by TGF-beta family members and regulates many physiological processes. HtrA1 is up-regulated in placenta during pregnancy and plays an important role in implantation and placental physiology. It regulates the availability of IGFs by cleaving IGF-binding proteins. It acts as a tumor suppressor and is down-regulated in ovarian cancers and melanomas. Its role has been implicated in osteoarthritis suggesting a therapeutic intervention. Northern blot analysis detected high expression in placenta.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: High-temperature requirement A serine peptidase 1; IGF binding; IGFBP5-protease; insulin-like growth factor binding protein 5 protease; L56; protease serine 11; protease, serine, 11; protease, serine, 11 (IGF binding); Serine protease 11; Serine protease HTRA1; similar to bacterial htrA and degP
Gene Aliases: AI429470; ARMD7; CADASIL2; CARASIL; HTRA; HTRA1; L56; ORF480; PRSS11; RSPP11
UniProt ID: (Human) Q92743, (Bovine) F1N152, (Rat) Q9QZK5, (Mouse) Q9R118
Entrez Gene ID: (Dog) 477852, (Human) 5654, (Bovine) 282326, (Rat) 65164, (Mouse) 56213
regulation of cell growth
placenta development
proteolysis
extracellular matrix disassembly
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of BMP signaling pathway
positive regulation of epithelial cell proliferation
negative regulation of defense response to virus
chorionic trophoblast cell differentiation
dentinogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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