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Proteintech
HTRA2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
15775-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HTRA2 Fusion Protein Ag8455 (133-458 aa encoded by BC000096)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.19 mg/mL
Amount
28.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: AAVPSPPPA SPRSQYNFIA DVVEKTAPAV VYIEILDRHP FLGREVPISN GSGFVVAADG LIVTNAHVVA DRRRVRVRLL SGDTYEAVVT AVDPVADIAT LRIQTKEPLP TLPLGRSADV RQGEFVVAMG SPFALQNTIT SGIVSSAQRP ARDLGLPQTN VEYIQTDAAI DFGNSGGPLV NLDGEVIGVN TMKVTAGISF AIPSDRLREF LHRGEKKNSS SGISGSQRRY IGVMMLTLSP SILAELQLRE PSFPDVQHGV LIHKVILGSP AHRAGLRPGD VILAIGEQMV QNAEDVYEAV RTQSQLAVQI RRGRETLTLY VTPEVTE (133-458 aa encoded by BC000096 )
Target Information
The inhibitor of apoptosis (IAP) family of proteins regulates programmed cell death triggered by various stimuli. All IAPs have at least one baculovirus IAP repeat (BIR) motif that is essential for their anti-apoptotic activity (1-3). Recently, a serine protease has been isolated, which is released from the mitochondria upon induction of apoptosis by apoptotic stimuli. This protein called Omi/HtrA2 is a mitochondrial protein that binds to IAP (4). Like Smac/DIABLO, the mature Omi protein contains a conserved IAP-binding motif (AVPS) at its N terminus. The deregulated expression of Omi in the cytoplasm of mammalian cells induces apoptosis indicating that Omi could participate in the mitochondrial apoptotic pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: epididymis secretory sperm binding protein; high temperature requirement protein A2; HtrA-like serine protease; motor neuron degeneration 2; Omi; Omi stress-regulated endoprotease; protease, serine, 25; serine protease 25; serine protease OMI; serine proteinase OMI; unnamed protein product
Gene Aliases: MGCA8; mnd2; OMI; PARK13; PRSS25
UniProt ID: (Human) O43464, (Mouse) Q9JIY5
Entrez Gene ID: (Human) 27429, (Mouse) 64704, (Rat) 297376
proteolysis
mitochondrion organization
adult walking behavior
adult locomotory behavior
intrinsic apoptotic signaling pathway in response to DNA damage
response to herbicide
programmed cell death
protein catabolic process
forebrain development
cellular response to oxidative stress
cellular response to heat
cellular response to interferon-beta
intracellular signal transduction
regulation of multicellular organism growth
positive regulation of apoptotic process
neuron development
neuron apoptotic process
cellular response to retinoic acid
cellular response to growth factor stimulus
intrinsic apoptotic signaling pathway
positive regulation of execution phase of apoptosis
regulation of mitophagy
negative regulation of parkin-mediated mitophagy in response to mitochondrial depolarization
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
protein autoprocessing
mitochondrial protein catabolic process
negative regulation of neuron apoptotic process
negative regulation of cell cycle
execution phase of apoptosis
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
positive regulation of establishment of protein localization to mitochondrion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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