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Invitrogen
HYAL1 Polyclonal Antibody
Advanced Verification
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
Product Details
PA5-51686
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human HYAL1. Recombinant protein control fragment (Product #RP-101871).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2642592
Product Specific Information
Immunogen sequence: SRALVQAQHP DWPAPQVEAV AQDQFQGAAR AWMAGTLQLG RALRPRGLWG FYGFPDCYNY DFLSPNYTGQ CPSGIRAQND QLGWLWGQSR ALYPSIYMPA VLEGTGKSQM YVQHRVAEAF RVAVAAGDPN LPVLPYVQIF YDTTNHF
Highest antigen sequence identity to the following orthologs: Mouse - 72%, Rat - 73%.
Target Information
This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Hyal-1; Hyaluronidase-1; Hyaluronoglucosaminidase-1; LuCa-1; Lung carcinoma protein 1; plasma hyaluronidase; tumor suppressor LUCA-1
Gene Aliases: HYAL-1; HYAL1; LUCA1; MPS9; NAT6
UniProt ID: (Human) Q12794
Entrez Gene ID: (Human) 3373
response to reactive oxygen species
carbohydrate metabolic process
inflammatory response
response to virus
positive regulation of epithelial cell migration
chondroitin sulfate catabolic process
hyaluronan metabolic process
hyaluronan biosynthetic process
hyaluronan catabolic process
positive regulation of cell growth
negative regulation of cell growth
cellular response to platelet-derived growth factor stimulus
cellular response to fibroblast growth factor stimulus
positive regulation of angiogenesis
positive regulation of cell adhesion
positive regulation of growth
response to antibiotic
positive regulation of epithelial cell proliferation
cartilage development
embryonic skeletal joint morphogenesis
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to pH
cellular response to UV-B
positive regulation of hyaluranon cable assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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