This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: SRALVQAQHP DWPAPQVEAV AQDQFQGAAR AWMAGTLQLG RALRPRGLWG FYGFPDCYNY DFLSPNYTGQ CPSGIRAQND QLGWLWGQSR ALYPSIYMPA VLEGTGKSQM YVQHRVAEAF RVAVAAGDPN LPVLPYVQIF YDTTNHF
Highest antigen sequence identity to the following orthologs: Mouse - 72%, Rat - 73%.
This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: HYAL-1; hyaluronidase 1; Hyaluronidase-1; Hyaluronoglucosaminidase-1; LuCa-1; LUCA1; Lung carcinoma protein 1; NAT6; plasma hyaluronidase; tumor suppressor LUCA-1
Gene Aliases: HYAL-1; HYAL1; LUCA1; MPS9; NAT6
UniProt ID: (Human) Q12794
Entrez Gene ID: (Human) 3373