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Proteintech
HYAL2 Polyclonal Antibody
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Product Details
15115-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HYAL2 Fusion Protein Ag7157 (99-448 aa encoded by BC000692)
Conjugate
Form
Liquid
Concentration
0.63 mg/mL
Amount
94.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: GVPQNVSLW AHRKMLQKRV EHYIRTQESA GLAVIDWEDW RPVWVRNWQD KDVYRRLSRQ LVASRHPDWP PDRIVKQAQY EFEFAAQQFM LETLRYVKAV RPRHLWGFYL FPDCYNHDYV QNWESYTGRC PDVEVARNDQ LAWLWAESTA LFPSVYLDET LASSRHGRNF VSFRVQEALR VARTHHANHA LPVYVFTRPT YSRRLTGLSE MDLISTIGES AALGAAGVIL WGDAGYTTST ETCQYLKDYL TRLLVPYVVN VSWATQYCSR AQCHGHGRCV RRNPSASTFL HLSTNSFRLV PGHAPGEPQL RPVGELSWAD IDHLQTHFRC QCYLGWSGEQ CQWDHRQAAG G (99-448 aa encoded by BC000692)
Target Information
This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Hyal-2; Hyaluronidase; hyaluronidase 2; Hyaluronidase-2; hyaluronoglucosaminidase 2; Hyaluronoglucosaminidase-2; LuCa-2; Lung carcinoma protein 2; lysosomal hyaluronidase; PH-20 homolog; PH-20 homolog; similar to the product encoded by GenBank Accession Number S67798; PH20 homolog; unnamed protein product
Gene Aliases: AI256841; AU020858; AW555733; HYAL2; LUCA2; MCCS
UniProt ID: (Human) Q12891, (Mouse) O35632
Entrez Gene ID: (Human) 8692, (Rat) 64468, (Mouse) 15587
virus receptor activity
transcription coactivator activity
hyalurononglucosaminidase activity
protein binding
hyaluronic acid binding
hydrolase activity
hydrolase activity, acting on glycosyl bonds
enzyme binding
receptor signaling protein tyrosine kinase inhibitor activity
receptor tyrosine kinase binding
hyaluronoglucuronidase activity
transforming growth factor beta binding
RNA polymerase II transcription coactivator activity
catalytic activity
glycosidase
response to reactive oxygen species
kidney development
hematopoietic progenitor cell differentiation
carbohydrate metabolic process
glycosaminoglycan catabolic process
response to virus
negative regulation of fibroblast migration
hyaluronan catabolic process
negative regulation of cell growth
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
positive regulation of urine volume
monocyte activation
positive regulation of protein import into nucleus
cellular response to fibroblast growth factor stimulus
positive regulation of transcription from RNA polymerase II promoter
response to antibiotic
viral entry into host cell
skeletal system morphogenesis
positive regulation of inflammatory response
cartilage development
defense response to virus
negative regulation of protein kinase B signaling
multicellular organismal iron ion homeostasis
renal water absorption
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to UV-B
cellular response to transforming growth factor beta stimulus
positive regulation of extrinsic apoptotic signaling pathway
multicellular organism aging
fusion of virus membrane with host plasma membrane
transformation of host cell by virus
negative regulation of MAP kinase activity
negative regulation of protein tyrosine kinase activity
positive regulation of interleukin-8 secretion
positive regulation of interleukin-6 secretion
metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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