PA5-30283 targets HYAL2 in WB applications and shows reactivity with Human samples.
The PA5-30283 immunogen is recombinant fragment corresponding to a region within amino acids 127 and 375 of Human HYAL2.
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This gene encodes a protein which is similar in structure to hyaluronidases. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. Varying functions have been described for this protein. It has been described as a lysosomal hyaluronidase which is active at a pH below 4 and specifically hydrolyzes high molecular weight hyaluronan. It has also been described as a GPI-anchored cell surface protein which does not display hyaluronidase activity but does serve as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.
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Protein Aliases: Hyal-2; hyaluronidase 2; Hyaluronidase-2; Hyaluronoglucosaminidase-2; LuCa-2; LUCA2; Lung carcinoma protein 2; lysosomal hyaluronidase; PH-20 homolog; PH20 homolog
Gene Aliases: AI256841; AU020858; AW555733; HYAL2; LUCA2