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Invitrogen
HYAL2 Polyclonal Antibody
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FIGURE: 1 / 1
HYAL2 Antibody (PA5-95061) in WB
Western blot analysis of HYAL2 in Lane 1: HeLa whole cell lysate (40 µg), Lane 2: SMMC whole cell lysate (40 µg), Lane 3: COLO320 whole cell lysate (40 µg), Lane 4: MCF-7 whole cell lysate (40 µg), Lane 5: HT1080 whole cell lysate (40 µg). Samples were incubated with HYAL2 polyclonal antibody (Product # PA5-95061).
Product Details
PA5-95061
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human HYAL2 (142-157aa VRNWQDKDVYRRLSRQ).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide, 0.05mg thimerosal
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: HELA whole cell, SMMC whole cell, COLO320 whole cell, MCF-7 whole cell, HT1080 whole cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Hyal-2; Hyaluronidase; hyaluronidase 2; Hyaluronidase-2; hyaluronoglucosaminidase 2; Hyaluronoglucosaminidase-2; LuCa-2; Lung carcinoma protein 2; lysosomal hyaluronidase; PH-20 homolog; PH-20 homolog; similar to the product encoded by GenBank Accession Number S67798; PH20 homolog; unnamed protein product
Gene Aliases: AI256841; AU020858; AW555733; HYAL2; LUCA2; MCCS
UniProt ID: (Human) Q12891, (Mouse) O35632
Entrez Gene ID: (Human) 8692, (Rat) 64468, (Mouse) 15587
virus receptor activity
transcription coactivator activity
hyalurononglucosaminidase activity
protein binding
hyaluronic acid binding
hydrolase activity
hydrolase activity, acting on glycosyl bonds
enzyme binding
receptor signaling protein tyrosine kinase inhibitor activity
receptor tyrosine kinase binding
hyaluronoglucuronidase activity
transforming growth factor beta binding
RNA polymerase II transcription coactivator activity
catalytic activity
glycosidase
response to reactive oxygen species
kidney development
hematopoietic progenitor cell differentiation
carbohydrate metabolic process
glycosaminoglycan catabolic process
response to virus
negative regulation of fibroblast migration
hyaluronan catabolic process
negative regulation of cell growth
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
positive regulation of urine volume
monocyte activation
positive regulation of protein import into nucleus
cellular response to fibroblast growth factor stimulus
positive regulation of transcription from RNA polymerase II promoter
response to antibiotic
viral entry into host cell
skeletal system morphogenesis
positive regulation of inflammatory response
cartilage development
defense response to virus
negative regulation of protein kinase B signaling
multicellular organismal iron ion homeostasis
renal water absorption
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to UV-B
cellular response to transforming growth factor beta stimulus
positive regulation of extrinsic apoptotic signaling pathway
multicellular organism aging
fusion of virus membrane with host plasma membrane
transformation of host cell by virus
negative regulation of MAP kinase activity
negative regulation of protein tyrosine kinase activity
positive regulation of interleukin-8 secretion
positive regulation of interleukin-6 secretion
metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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