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Invitrogen
HYOU1 Polyclonal Antibody
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FIGURE: 1 / 3
HYOU1 Antibody (PA5-109841) in IHC (P)
Immunohistochemistry analysis of HYOU1 in paraffin-embedded human vermiform appendix. Samples were incubated with HYOU1 Polyclonal antibody (Product # PA5-109841) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-109841
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment)
Conjugate
Form
Liquid
Concentration
0.52 mg/mL
Amount
52 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MADKVRRQRP RRRVCWALVA VLLADLLALS DTLAVMSVDL GSESMKVAIV KPGVPMEIVL NKESRRKTPV IVTLKENERF FGDSAASMAI KNPKATLRYF QHLLGKQADN PHVALYQARF PEHELTFDPQ RQTVHFQISS
Target Information
HYOU1 belongs to the heat shock protein 70 family. The protein is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 140 kDa Ca(2+)-binding protein; 150 kDa oxygen-regulated protein; 150-kDa oxygen regulated protein; 170 kDa glucose regulated protein GRP170; 170 kDa glucose-regulated protein; calcium binding protein 140; calcium binding protein, 140 kDa; CBP-140; DKFZp686N08236; epididymis secretory sperm binding protein; FLJ94899; FLJ97572; Grp 170; GRP-170; Heat shock protein family H member 4; HSP 12A; Hypoxia up-regulated protein 1; Orp 150; ORP-150; ORP150; oxygen regulated protein (150kD); unnamed protein product
Gene Aliases: AI415631; Cab140; CBP-140; GRP-170; GRP170; HSP12A; HSPH4; HYOU1; IMD59; ORP-150; ORP150
UniProt ID: (Human) Q9Y4L1, (Mouse) Q9JKR6
Entrez Gene ID: (Human) 10525, (Mouse) 12282
response to ischemia
protein folding
ER to Golgi vesicle-mediated transport
response to stress
response to endoplasmic reticulum stress
negative regulation of apoptotic process
cellular response to hypoxia
regulation of cellular response to stress
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
negative regulation of intrinsic apoptotic signaling pathway
response to hypoxia
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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