Immunogen sequence: MVSHHNLTT GATLINEQWL LTTAKNLFLN HSENATAKDI APTLTLYVGK KQLVEIEKVV LHPNYSQVDI GLIKLKQKVS VNERVMPICL PSKDYAEVGR VGYVSGWGRN ANFKFTDHLK YVMLPVADQD QCIRHYEGST VPEKKTPKSP VGVQPILNEH TFCAGMSKYQ EDTCYGDAGS AFAVHDLEED TWYATGILSF DKSCAVAEYG VYVKVTSIQD WVQKTIAEN (179-406 aa encoded by BC058031)
Haptoglobin is an a2-globulin plasma protein synthesized in the liver. It is an acute phase protein which also acts as a scavenger of hemoglobin from hemolyzed red cells. The haptoglobin monomer consists of two a and two beta chains; the a chains bay be hp1Fa, hp1Sa, or hp2a types while the beta chain is constant. Three major phenotypes are recognized: HP1-1, Hp2-1 and Hp-2-2, in which the hp1a chain bay be either the F or S type.
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Protein Aliases: alpha polypeptide; beta polypeptide; binding peptide; Binding peptide (BP); Haptoglobin; Haptoglobin alpha chain; Haptoglobin alpha chain / alpha(1S) beta; haptoglobin alpha(1S)-beta; Haptoglobin alpha(2FS) beta; haptoglobin alpha(2FS)-beta; Haptoglobin beta chain; haptoglobin, alpha polypeptide; haptoglobin, beta polypeptide; HP2 ALPHA2; HP2-ALPHA-2; HPT; Liver regeneration-related protein LRRG173; MGC111141; MGC133752; Zonulin
Gene Aliases: Ba1-647; BP; HP; HP-1; HP2ALPHA2; HPA1S; preHP2
Molecular Function: serine protease