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Invitrogen
Haptoglobin beta Polyclonal Antibody
Product Details
PA5-142825
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
0.1 µg/mL | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Pig |
Host/Isotype |
Goat / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Peptide with sequence C-STVPEKKTPKSP. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.5 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
TBS, pH 7.3, with 0.5% BSA |
Contains |
0.02% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
Product Specific Information
Additional Information: This antibody is expected to recognize both reported isoforms (NP_005134.1; NP_001119574.1).
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:8,000.
Target Information
As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. [PMID: 21248165]. The uncleaved form of allele alpha-2 (2-2), known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens. [PMID: 21248165]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: binding peptide; Haptoglobin; haptoglobin alpha 1S; Haptoglobin alpha chain; haptoglobin alpha(1S)-beta; haptoglobin alpha(2FS)-beta; Haptoglobin beta chain; haptoglobin, alpha polypeptide; haptoglobin, beta polypeptide; Zonulin
Gene Aliases: BP; HP; HP2ALPHA2; HPA1S
UniProt ID: (Human) P00738, (Pig) Q8SPS7
Entrez Gene ID: (Human) 3240, (Pig) 397061
Molecular Function:
serine protease
immune system process
receptor-mediated endocytosis
defense response
acute-phase response
positive regulation of cell death
response to hydrogen peroxide
defense response to bacterium
negative regulation of oxidoreductase activity
cellular oxidant detoxification
negative regulation of hydrogen peroxide catabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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