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Invitrogen
Hepsin Polyclonal Antibody
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Product Details
PA5-82265
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human HPN. Recombinant protein control fragment (Product #RP-89245).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: FDKTEGTWRL LCSSRSNARV AGLSCEEMGF LRALTHSELD VRTAGANGTS GFFCVDEGRL PHTQRLLEVI SVCDCPRGRF LAAICQDCGR RKLPVDRIVG GRDTSLGRWP WQVSLRYDGA HL
Highest antigen sequence indentity to the following orthologs: Mouse - 91%, Rat - 90%.
Target Information
Hepsin, encoded by the HPN gene, is a type II transmembrane serine protease prominently expressed in tissues such as the liver, kidney, and prostate. Hepsin plays a crucial role in proteolytic processes involved in extracellular matrix remodeling, cell growth, and development. It is known for activating precursor molecules, including hepatocyte growth factor (HGF), which is essential for liver development and regeneration. Furthermore, hepsin's involvement extends to influencing cell signaling pathways related to tissue homeostasis and repair. In the context of cancer, particularly prostate cancer, hepsin is implicated in tumor progression and metastasis by promoting extracellular matrix degradation, thereby facilitating tumor invasion and spread. Aberrant expression or activity of hepsin is associated with pathophysiological changes in the tumor microenvironment, making it a target for therapeutic interventions aimed at controlling cancer progression. Research continues to explore hepsin's biochemical functions and regulatory mechanisms, providing insights into its potential roles in both normal physiology and disease states.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Serine protease hepsin; testicular tissue protein Li 85; Transmembrane protease serine 1
Gene Aliases: HPN; TMPRSS1
UniProt ID: (Human) P05981
Entrez Gene ID: (Human) 3249
proteolysis
regulation of cell shape
positive regulation of gene expression
negative regulation of epithelial to mesenchymal transition
positive regulation of plasminogen activation
positive regulation of cell growth
basement membrane disassembly
negative regulation of apoptotic process
positive regulation by host of viral transcription
hepatocyte growth factor receptor signaling pathway
negative regulation of epithelial cell proliferation
detection of mechanical stimulus involved in sensory perception of sound
potassium ion transmembrane transport
cochlea morphogenesis
response to thyroid hormone
pilomotor reflex
positive regulation of hepatocyte proliferation
positive regulation of thyroid hormone generation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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