Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The nucleosomes wrap further and compact DNA into chromotin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones play a central role in transciption regulation, DNA repair, DNA replication, and chromosomal stability. H2B has a broad antibacterial activity.
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Protein Aliases: H2b 613; H2B histone family, member A; H2B histone family, member F; H2B histone family, member K; H2B histone family, member L; H2B histone family, member Q; H2B histone family, member S; H2B histone family, member T; H2B histone family, member U, (testis-specific); H2B K; h2B-143; H2B/a; H2B/f; H2B/g; H2B/h; H2B/k; H2B/l; H2B/q; H2BFS; HIRA-interacting protein 1; histone 1, H2ba; histone 1, H2bb; histone 1, H2bc; histone 1, H2bg; histone 1, H2bi; histone 1, H2bk; histone 2, H2be; histone cluster 1, H2bc; histone cluster 2, H2be; histone family member; histone H2B; Histone H2B type 1-A; Histone H2B type 1-B; Histone H2B type 1-C/E/F/G/I; Histone H2B type 1-C/E/G; Histone H2B type 1-K; Histone H2B type 2-E; Histone H2B type 2-F; Histone H2B, testis; Histone H2B-GL105; Histone H2B.1; Histone H2B.1 A; Histone H2B.a; Histone H2B.f; Histone H2B.g; Histone H2B.h; Histone H2B.k; Histone H2B.l; Histone H2B.q; testis-specific histone 2b; Testis-specific histone H2B; TSH2B.1
Gene Aliases: 2610022J01Rik; AV127319; bA317E16.3; dJ221C16.3; dJ221C16.8; GL105; H2B; H2b-143; H2b-613; H2B.1; H2B.1A; H2B/a; H2B/f; H2B/k; H2B/l; H2B/S; H2BC10; H2BC4; H2BC6; H2BC7; H2BC8; H2BFA; H2BFAiii; H2BFF; H2BFG; H2BFH; H2BFK; H2BFL; H2BFQ; H2bfs; H2BFT; H2BFU; H2BGL105; H2BK; H2BQ; HIRIP1; HIST1H2BA; HIST1H2BB; HIST1H2BC; HIST1H2BE; HIST1H2BF; HIST1H2BG; HIST1H2BI; HIST1H2BK; HIST2H2BE; HIST2H2BF; R74621; RGD1562346; STBP; T25626; TH2B; TSH2B; TSH2B.1
UniProt ID: (Human) Q96A08, (Human) P33778, (Human) P62807, (Human) P62807, (Human) P62807, (Human) O60814, (Human) Q16778, (Human) Q5QNW6, (Mouse) P70696, (Rat) Q00729, (Mouse) Q64475, (Mouse) Q6ZWY9, (Mouse) Q6ZWY9, (Mouse) Q8CGP1, (Mouse) Q64524
Entrez Gene ID: (Human) 255626, (Human) 3018, (Human) 8347, (Human) 8339, (Human) 8346, (Human) 85236, (Human) 8349, (Human) 440689, (Mouse) 319177, (Rat) 24829, (Mouse) 319178, (Mouse) 68024, (Mouse) 319181, (Mouse) 319184, (Rat) 680312, (Rat) 295274, (Mouse) 319190