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Invitrogen
Hopx Polyclonal Antibody
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Product Details
PA5-56390
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human Hopx. Recombinant protein control fragment (Product #RP-95528).
Conjugate
Form
Liquid
Concentration
0.30 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MLIFLGCYRR RLEERAGTMS AETASGPTED QVEILEYNFN KVDKHPDSTT LCLIAAEAGL SEEETQKWFK QRLAKWRRSE GLPSECRSVT D
Highest antigen sequence identity to the following orthologs: Mouse - 74%, Rat - 74%.
Target Information
HOPX is an atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. HOPX acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. HOPX prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. HOPX overexpression causes cardiac hypertrophy and may act as a tumor suppressor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Homeodomain-only protein; Lung cancer-associated Y protein; not expressed in choriocarcinoma clone 1; Not expressed in choriocarcinoma protein 1; Odd homeobox protein 1
Gene Aliases: CAMEO; HOD; HOP; HOPX; LAGY; NECC1; OB1; SMAP31; TOTO
UniProt ID: (Human) A8K0Z2
Entrez Gene ID: (Human) 84525
negative regulation of transcription from RNA polymerase II promoter
trophectodermal cell differentiation
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
heart development
regulation of heart contraction
histone deacetylation
regulation of protein binding
positive regulation of skeletal muscle tissue regeneration
negative regulation of cell differentiation
lung alveolus development
positive regulation of striated muscle cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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